Results 51 to 60 of about 21,598 (219)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Failure mode and effects analysis applied to central venous catheter placement

BMJ Open Quality
Despite diligent efforts, complications continue to occur during the placement of central venous catheters (CVCs). Healthcare Failure Mode and Effect Analysis has been promoted as a process improvement tool and this review describes the strategic ...
Daniel Harwood, Bruno Maranhao, James R Duncan, Ellen Wertenberger, Jacob Grant, Mona Ostman   +5 more
doaj   +1 more source

Research progress in the application of different management models in fall prevention of patients

Huli yanjiu, 2021
This paper reviewed the research progress of healthcare failure mode and effect analysis，Swiss cheese model，bundles of care model，multidisciplinary collaboration model，comprehensive unit⁃based safety program and so on in fall prevention of patients.It ...
LIU Yuxiu, SHANG Linping
doaj  

Penerapan Healthcare Failure Mode and Effect Analysis (HFMEA) pada Implementasi Rekam Medis Elektronik

Jurnal Kesehatan Vokasional
Latar Belakang: Rekam Medis Elektronik (RME) terbukti meningkatkan kualitas layanan kesehatan. Namun, penerapannya belum mencapai target yang diharapkan, berisiko terhadap kepuasan dan keselamatan pasien, bahkan terancam gagal.
Ellya - Yudianti, Merita - Arini
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

PROCESSO DE INSERÇÃO, MANUTENÇÃO E RETIRADA DE CATETER INTRAVENOSO PERIFÉRICO: ANÁLISE PREVENTIVA DE RISCOS

Cogitare Enfermagem, 2023
Objetivo: demonstrar a aplicabilidade da ferramenta Healthcare Failure Mode and Effect Analysis para analisar, preventivamente, os riscos relativos ao processo de inserção, manutenção e retirada de cateter intravenoso periférico. Método: estudo teórico,
Maryana da Silva Furlan, Amanda Saba, Simone Berger, Antônio Fernandes Costa Lima   +3 more
doaj   +1 more source

The application of healthcare failure mode and effect analysis in reducing medication errors in the emergency department of Regional Public Hospital

Indonesia Journal of Biomedical Science
Introduction: Medication or medication error is an essential issue in the world of health, both in the world and in Indonesia. The emergency department is a health service unit that provides emergency services 24 hours non-stop, which is very likely for ...
Nurul Fitrah, E. Rosa
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source