Results 61 to 70 of about 234,626 (289)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

RF communication with implantable wireless device: effects of beating heart on performance of miniature antenna [PDF]

, 2014
The frequency response of an implantable antenna is key to the performance of a wireless implantable sensor. If the antenna detunes significantly, there are substantial power losses resulting in loss of accuracy.
Bahmanyar, MR, Borghi, A, McLeod, CN, Murphy, OH, Navaratnarajah, M, Toumazou, C, Yacoub, M   +6 more
core   +1 more source

Failure mode and effects analysis applied to central venous catheter placement

BMJ Open Quality
Despite diligent efforts, complications continue to occur during the placement of central venous catheters (CVCs). Healthcare Failure Mode and Effect Analysis has been promoted as a process improvement tool and this review describes the strategic ...
Daniel Harwood, Bruno Maranhao, James R Duncan, Ellen Wertenberger, Jacob Grant, Mona Ostman   +5 more
doaj   +1 more source

Research progress in the application of different management models in fall prevention of patients

Huli yanjiu, 2021
This paper reviewed the research progress of healthcare failure mode and effect analysis，Swiss cheese model，bundles of care model，multidisciplinary collaboration model，comprehensive unit⁃based safety program and so on in fall prevention of patients.It ...
LIU Yuxiu, SHANG Linping
doaj  

PROCESSO DE INSERÇÃO, MANUTENÇÃO E RETIRADA DE CATETER INTRAVENOSO PERIFÉRICO: ANÁLISE PREVENTIVA DE RISCOS

Cogitare Enfermagem, 2023
Objetivo: demonstrar a aplicabilidade da ferramenta Healthcare Failure Mode and Effect Analysis para analisar, preventivamente, os riscos relativos ao processo de inserção, manutenção e retirada de cateter intravenoso periférico. Método: estudo teórico,
Maryana da Silva Furlan, Amanda Saba, Simone Berger, Antônio Fernandes Costa Lima   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart [PDF]

, 2014
Background: Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism.
Aksentijević, Dunja, Faller, Kiterie M.E., Lygate, Craig A., McAndrew, Debra J., Neubauer, Stefan, Schneider, Jurgen E., Zazueta, Cecilia, Zervou, Sevasti   +7 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain [PDF]

, 2018
Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated with considerable morbidity, mortality and economic impact.
Aceituno, Susana, Aragón, Belén, Cobo, Javier, Grau, Santiago, Jiang, Yiling, Maratia, Stefano, Pascual, Álvaro, Salavert, Miguel   +7 more
core   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source