Results 91 to 100 of about 17,104,245 (298)

Inequity in healthcare needs, health service use and financial burden of medical expenditures in China: results from a consecutive household monitoring study in Jiangsu Province

BMC Health Services Research, 2019
Background Although public medical insurance covers over 95% of the population in China, disparities in health service use and out-of-pocket (OOP) health expenditure across income groups are still widely observed. This study aims to investigate the socio-
Weixi Jiang, Xiaolin Xu, Shenglan Tang, Ling Xu, Yaoguang Zhang, Chris Elbers, Frank Cobelens, Lijing Yan   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

2020 National Healthcare Safety Network antimicrobial use option report [PDF]

Monitoring antimicrobial use (AU) is an important component of antibiotic stewardship programs (ASPs). AU data delivered to ASPs enable stewards to develop, select, and assess interventions aimed at optimizing antimicrobial prescribing.

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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

2019 National Healthcare Safety Network antimicrobial use option report [PDF]

Monitoring antimicrobial use (AU) is an important component of antibiotic stewardship programs (ASPs). AU data delivered to ASPs enable stewards to develop, select, and assess interventions aimed at optimizing antimicrobial prescribing.

core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Economic gains from hypothetical improvements in the psychosocial work environment: A cohort study of 71 207 workers in Denmark

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: There is increasing interest in the economic effects of improving working conditions, however, evidence is sparse. This study aims to estimate the economic effects of hypothetical improvements in the psychosocial work environment (PSWE ...
Brian Krogh Graversen, Kristian Schultz Hansen, Reiner Rugulies, Jeppe Karl Sørensen, Ann Dyreborg Larsen   +4 more
doaj   +1 more source

How clinicians should prioritise the use of artificial intelligence in Singapore’s healthcare system: Correspondence

Annals, Academy of Medicine, Singapore
The readers writing this letter read with interest Hwang et al.’s article on augmented intelligence in healthcare,1 and agree that it would be most responsible for artificial intelligence (AI) to enhance, rather than replace clinical judgment.
Mattias Wei Ren Kon, John Abisheganaden, Gary Yee Ang   +2 more
doaj   +1 more source

SustiNet Healthcare Workforce Task Force report

, 2010
Title from PDF cover (SustiNet web site, viewed Sept. 10, 2010).; "Pursuant to PA 09-148, An Act Concerning the Establishment of the SustiNet Plan ..."--Letter of transmittal.; "July 1, 2010."; Includes bibliographical ...
Connecticut. SustiNet Healthcare Workforce Task Force.
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