Results 101 to 110 of about 17,104,245 (298)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A comparative appraisal of stigma among healthcare workers towards alcohol and substance use disorders: a case vignette study

Frontiers in Psychiatry
IntroductionAlcohol and substance use disorders contribute significantly to the global burden of disease, resulting in substantial morbidity and mortality.
Onat Yilmaz, Alparslan Asil Budakli, Eda Aslan   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Use of benzodiazepines and medications for opioid use disorder for withdrawal management in a hospital-based setting for individuals exposed to benzodiazepine-contaminated fentanyl: A case series

Drug and Alcohol Dependence Reports
Objectives: The objective of our study was to evaluate medication-related safety, tolerability and preliminary effectiveness of short-term benzodiazepine tapers to manage atypical withdrawal syndromes among individuals with opioid use disorder (OUD ...
Alexander Wong, Seonaid Nolan, Paxton Bach, Renée M. Janssen, Travis J. De Wolfe, Piper Dickhout, Rhea Beauchesne, Felicia Yang, Cheyenne Johnson, Addie Carter, Bohdan Nosyk, Brittany B. Dennis   +11 more
doaj   +1 more source

2021 National Healthcare Safety Network antimicrobial use option report [PDF]

The 2021 NHSN AU Option Report (2021 AU Report) provides a summary of SAAR distributions and of antibiotic use within each SAAR antimicrobial agent category among adult, pediatric, and neonatal patient care locations (specified below).

core  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Is loneliness associated with cancellation of medical appointments during the COVID-19 pandemic? Evidence from the Hamburg City Health Study (HCHS)

BMC Health Services Research
Background The COVID-19 pandemic engendered numerous societal and economic challenges in addition to health-related concerns. Maintenance of healthcare utilization assumed immense significance during this period.
A. Hajek, E. Petersen, I. Schäfer, V. Harth, U. Koch-Gromus, M. Härter, H. Schulz, M. Scherer, H.H. König   +8 more
doaj   +1 more source

Impact of the COVID-19 Pandemic on Incidence of Asthma Exacerbations and Hospitalizations in US Subspecialist-Treated Patients with Severe Asthma: Results from the CHRONICLE Study

Journal of Asthma and Allergy, 2022
Wendy C Moore,1 Dennis K Ledford,2 Donna D Carstens,3 Christopher S Ambrose4 1Wake Forest School of Medicine Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston-Salem, NC, USA; 2Morsani College ...
Moore WC, Ledford DK, Carstens DD, Ambrose CS   +3 more
doaj  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source