Results 111 to 120 of about 902,300 (312)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

AIDS at Work: The SEIU AIDS Project [PDF]

open access: yes, 1990
[Excerpt] In the early stages of the AIDS epidemic, AIDS was primarily an urban phenomenon, appearing first among gay men, intravenous (I.V.) drug users and their sexual partners.
Mehring, John
core   +1 more source

Ebola virus infection among western healthcare workers unable to recall the transmission route [PDF]

open access: yes, 2016
Introduction. During the 2014-2016 West-African Ebola virus disease (EVD) outbreak, some HCWs from Western countries became infected despite proper equipment and training on EVD infection prevention and control (IPC) standards.
Messano, GIUSEPPE ALESSIO   +3 more
core   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Factors Affecting Performance of Healthcare Workers During COVID-19 in Pakistan

open access: yesSpace and Culture, India, 2020
Healthcare workers are one of the most affected communities at the global level during the pandemic of COVID-19, and Pakistan is no exception. Pakistan allocates merely less than 1% of its GDP for the healthcare sector, that is why, in most of the cases,
Muhammad Jafar, Aisha Shoukat
doaj   +1 more source

It's Not Easy Being Gray: The New Rules of Retirement [PDF]

open access: yes, 2009
Examines changes in the factors involved in retirement, including the labor market for older workers, demands and limitations of working longer, the effect of rising healthcare costs, and adequacy of retirement income.

core  

Legal and illegal drug use among female sex workers in bar and club prostitution in Belgium: a quantitative and qualitative study [PDF]

open access: yes, 2013
Aims: This study describes the amounts and effects of drug use in bar and club sex work, and the use of healthcare for the drug-related needs of sex workers (SW). Methods: A cross-sectional study was carried out in Belgium.
Decorte, Tom   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Evaluating a framework for tuberculosis screening among healthcare workers in clinical settings, Inner Mongolia, China

open access: yesJournal of Occupational Medicine and Toxicology, 2018
Background Health care workers are at high risk for tuberculosis (TB). China, a high burden TB country, has no policy on medical surveillance for TB among healthcare workers.
Shiming Cheng   +19 more
doaj   +1 more source

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