Results 41 to 50 of about 319,822 (245)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

LEVEL OF KNOWLEDGE AND COMPLIANCE WITH PERSONAL PROTECTIVE EQUIPMENT USE IN HEALTHCARE WORKERS

Jurnal Berkala Epidemiologi, 2022
Background: The effort to control and prevent COVID-19 in health facilities is to optimize the use of Personal Protective Equipment (PPE) according to guidelines set by the government.
Reza Fajrinmuha, Nuraini Wulandiana, Ratna Dwi Wulandari, Nyoman Anita Damayanti   +3 more
doaj   +1 more source

Cardiac misconceptions in healthcare workers

European Journal of Cardiovascular Nursing, 2011
Cardiac misconceptions are common and may have a detrimental effect on patients. Such misconceptions may be introduced or reinforced by vague and inconsistent advice from healthcare staff and can adversely affect health outcomes.To assess whether level of cardiac misconceptions significantly differs between groups of healthcare staff based on ...
Angus, Neil, Patience, Fiona, Maclean, Elizabeth, Corrigall, Helen, Bradbury, Ian, Thompson, David, Atherton, Iain, Leslie, Stephen J.   +7 more
openaire   +6 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Violence against healthcare workers [PDF]

International Orthopaedics, 2013
The objective of SICOT is "to promote the advancement of the science and art of orthopaedics and traumatology at international level in particular for the improvement of patient care; to foster and develop teaching, research and education; to facilitate and encourage exchange of professional experience and to promote good fellowship among its members."
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Measles and Varicella Vaccination Program in a Hospital: Implementation and Impact on Contact Tracing

Vaccines, 2023
Healthcare workers are recommended to get vaccinated against measles and varicella. This study aims to describe the implementation process of a measles and varicella vaccination program and report on the reduction in the number of susceptible healthcare ...
Alicia Siew Ting Loi, Revathi Sridhar, See Ming Lim   +2 more
doaj   +1 more source

Workplace Bullying among Healthcare Workers [PDF]

International Journal of Environmental Research and Public Health, 2013
This paper aims to assess consistent predictors through the use of a sample that includes different actors from the healthcare work force to identify certain key elements in a set of job-related organizational contexts. The utilized data were obtained from the 5th European Working Conditions Survey, conducted in 2010 by the European Foundation for the ...
Ariza Montes, José Antonio, Muñiz Rodríguez, Noel Martín, Montero Simó, María José, Araque Padilla, Rafael Ángel   +3 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hair tourniquet syndrome leading to nipple autoamputation in an adult female: a case report

Frontiers in Surgery
This is a unique case of hair thread tourniquet syndrome (HTTS) affecting the nipple of an adult female, leading to spontaneous autoamputation, a phenomenon rarely documented in the literature for this anatomical site.
Alaa A. Alshurafa, Alaa A. Alshurafa, Khaled Alshawwa, Khaled Alshawwa   +3 more
doaj   +1 more source