Results 51 to 60 of about 319,822 (245)

Difficulties facing healthcare workers in the era of AIDS treatment in Lesotho

SAHARA-J, 2016
Sub-Saharan Africa is most affected by the AIDS pandemic and Lesotho is no exception. In many countries, healthcare workers are at the forefront of the fight against AIDS.
Masebeo Veronica Koto, Pranitha Maharaj
doaj   +1 more source

Etiological explanation, treatability and preventability of childhood autism: a survey of Nigerian healthcare workers' opinion

Annals of General Psychiatry, 2009
Background Because of their peculiar sociocultural background, healthcare workers in sub-Saharan African subcultures may have various conceptions on different aspects of autism spectrum disorders (ASD), such as etiology, treatment and issues of prognosis.
Okonkwo Kevin O, Eaton Julian, Ebigbo Peter O, Agomoh Ahamefule O, Bakare Muideen, Onwukwe Jojo U, Onyeama Gabriel M   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Drivers and mediators of healthcare workers’ anxiety in one of the most affected hospitals by COVID-19: a qualitative analysis

BMJ Open, 2021
Objective To report the driving and mediating factors of healthcare workers’ anxiety during the COVID-19 pandemic.Design Qualitative indepth interview study.Setting The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and
Tian Tian, Mengling Fang, Bo Xia, Yan Hao, Zhenghao Wu   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Violence Against Healthcare Workers

Patient Safety, 2019
While working in healthcare has always carried an inherent amount of danger, I can tell you with certainty that the last time I was a staff nurse (in the spirit of transparency—it’s been a while) I never once feared going to work.
Regina Hoffman
doaj  

Anti–SARS-CoV Immunoglobulin G in Healthcare Workers, Guangzhou, China

Emerging Infectious Diseases, 2005
To determine the prevalence of inapparent infection with severe acute respiratory syndrome (SARS) among healthcare workers, we performed a serosurvey to test for immunoglobulin (Ig) G antibodies to the SARS coronavirus (SARS-CoV) among 1,147 healthcare ...
Wei-Qing Chen, Ci-Yong Lu, Tze-wai Wong, Wen-Hua Ling, Zhong-Ning Lin, Yuan-Tao Hao, Qing Liu, Ji-Qian Fang, Yun He, Fu-Tian Luo, Jin Jing, Li Ling, Xiang Ma, Yi-Min Liu, Gui-Hua Chen, Jian Huang, Yuan-Sen Jiang, Wen-Qi Jiang, He-Qun Zou, Guang-Mei Yan   +19 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Job burnout among Israeli healthcare workers during the first months of COVID-19 pandemic: The role of emotion regulation strategies and psychological distress.

PLoS ONE, 2022
The current worldwide COVID-19 pandemic has elicited widespread concerns and stress. Arguably, healthcare workers are especially vulnerable to experience burnout during these times due to the nature of their work.
Marlyn Khouri, Dana Lassri, Noga Cohen
doaj   +1 more source

Psychological aid for frontline healthcare workers

Clinical neuropsychiatry, 2020
Given the challenges of COVID-19, practical measures including psychological support for frontline healthcare workers are essential. The aim of this article is to provide psychological aid to frontline healthcare professionals based on evidence-based practices.
Gloster, Andrew T., Zacharia, Marianna, Karekla, Maria   +2 more
openaire   +3 more sources