Results 71 to 80 of about 319,822 (245)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Prevalence and factors associated with occupational burnout among HIV/AIDS healthcare workers in China: a cross-sectional study

BMC Public Health, 2016
Background Burnout is a psychosomatic syndrome characterized by three dimensions (emotional exhaustion [EE], feelings of depersonalization [DP], and reduced personal accomplishment [PA]).
Zhengxue Qiao, Lu Chen, Mingqi Chen, Xin Guan, Lin Wang, Yang Jiao, Jiarun Yang, Qinghua Tang, Xiuxian Yang, Xiaohui Qiu, Dong Han, Jingsong Ma, Yanjie Yang, Xiuwei Zhai   +13 more
doaj   +1 more source

Influenza vaccination in healthcare workers

The Journal of Infection in Developing Countries, 2009
This study aims to determine side effects in healthcare workers receiving influenza vaccination, and to scrutinize the opinion of and attitude toward vaccination of healthcare workers.Five hundred forty-seven hospital personnel employed by the Eskişehir Yunus Emre State Hospital were included in the study which was conducted in November 2006,. Hospital
Hasan Naz, Figen Cevik, Nevil Aykın
openaire   +4 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Factors Affecting Performance of Healthcare Workers During COVID-19 in Pakistan

Space and Culture, India, 2020
Healthcare workers are one of the most affected communities at the global level during the pandemic of COVID-19, and Pakistan is no exception. Pakistan allocates merely less than 1% of its GDP for the healthcare sector, that is why, in most of the cases,
Muhammad Jafar, Aisha Shoukat
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Evaluating a framework for tuberculosis screening among healthcare workers in clinical settings, Inner Mongolia, China

Journal of Occupational Medicine and Toxicology, 2018
Background Health care workers are at high risk for tuberculosis (TB). China, a high burden TB country, has no policy on medical surveillance for TB among healthcare workers.
Shiming Cheng, Deanna Tollefson, Guangxue He, Yuan Li, Hui Guo, Shua Chai, Fangfang Gao, Fei Gao, Guoxin Han, Liping Ren, Yulin Ren, Jianbo Li, Lixia Wang, Jay K. Varma, Dongmei Hu, Haiying Fan, Fei Zhao, Emily Bloss, Yu Wang, Carol Y. Rao   +19 more
doaj   +1 more source

Avian Influenza H5N1 and Healthcare Workers

Emerging Infectious Diseases, 2005
Al editor: Desde enero de 2004, se han reportado 35 casos humanos del virus de la influenza aviar A H5N1 en Vietnam. La transmisión de persona a persona del H5N1 es una preocupación importante, particularmente debido a la agrupación familiar informada (1). Recientemente se informaron dos casos probables de transmisión de persona a persona en Tailandia (
Constance Schultsz, Vo Cong Dong, Nguyễn Văn Vĩnh Châu, Nguyen Le, Wilina Lim, Tran Tan Thanh, Christiane Dolecek, Menno D. de Jong, Tran Tinh Hien, Jeremy Farrar   +9 more
openaire   +4 more sources