Results 81 to 90 of about 2,809,630 (303)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Isoniazid Prophylaxis of Latent Tuberculous Infection among Healthcare Workers in Bamrasnaradura Infectious Diseases Institute

Siriraj Medical Journal, 2016
Background: Treatment of latent tuberculosis infection (LTBI) is one of the essential measures for tuberculosis (TB) control. The tuberculin skin test (TST) is an important tool for the detection of LTBI and the identification of healthcare workers ...
Patama Suttha, Pranom Noppakun, Patchara Tanthirapat, Boonchai Kowadisaiburana   +3 more
doaj  

Stakeholders' Perceptions on Shortage of Healthcare Workers in Primary Healthcare in Botswana: Focus Group Discussions.

PLoS ONE, 2015
BackgroundAn adequate health workforce force is central to universal health coverage and positive public health outcomes. However many African countries have critical shortages of healthcare workers, which are worse in primary healthcare. The aim of this
Oathokwa Nkomazana, Robert Mash, Sheila Shaibu, Nthabiseng Phaladze   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Comparison of Serratus Anterior and Abdominal Muscle Activity During Push-up Plus Exercise With Hip Adduction and the Abdominal Drawing-in Maneuver

Physical Therapy Korea
Background: The serratus anterior (SA) is a muscle that performs protraction of the scapulothoracic joint and plays a role in stabilizing the scapula.
Sang-hyuk Lee, Jun-hee Kim, Oh-yun Kwon
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Healthcare Workers

Journal of Occupational & Environmental Medicine, 2020
Belingheri, Michael, Paladino, Maria Emilia, Riva, Michele Augusto   +2 more
openaire   +4 more sources

Meningococcal disease and healthcare workers

BMJ, 1999
Although Neisseria meningitidis is a relatively uncommon cause of overt infection (2580 notifications in 1998),1 the horrors of its clinical presentation have stimulated intense media interest, particularly after outbreaks. With the disappearance of many infectious competitors in the latter half of this century, meningococcal disease has become the ...
Pollard, A, Begg, N
openaire   +3 more sources

Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.

, 2023
Methicillin-resistant (MRSA) constitutes a serious public health concern, with a considerable impact on patients’ health, and substantial healthcare costs.
S.C.J. De Keersmaecker, K. Vanneste, N. Roosens, B. Bogaerts, L.Carine Yehouenou, A.A. Kpangon, O. Dalleur, A. Dissou, A. Simon, F.Moise Dossou   +9 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source