Results 121 to 130 of about 429,551 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Effects of the MONOZUKURI Program on Executive Function Among Community‐Dwelling Older Adults: A Randomized Controlled Trial

Brain and Behavior
Introduction This study aimed to examine the effect of the MONOZUKURI program, a cognitive intervention related to creative activities (handicrafts and creative cooking), on cognitive function in community‐dwelling older adults.
Ai Iizuka, Susumu Ogawa, Daisuke Cho, Kyoko Fujihira, Yan Li, Kenichiro Sato, Keigo Hinakura, Kimi Estela Kobayashi‐Cuya, Hiroyuki Suzuki   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Heparanase modulates synaptic plasticity at the hippocampus [PDF]

, 2009
The 5th International Symposium on Health Aging, Hong Kong, 6-7 March 2010.
Cham, WC, Xie, H, Ma, CW, Zhang, Y, Yung, WH, Shum, DKY, Chan, YS   +6 more
core  

Longevity as a Responsibility: Constructing Healthy Aging by Enacting within Contexts over the Entire Lifespan [PDF]

Studying aging now requires going beyond the bio-psycho-social model and incorporating a broader multidisciplinary view capable of capturing the ultimate complexity of being human that is expressed as individuals age.
Morganti, Francesca, Francesca Morganti
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline

Communications Medicine
Background Physio-cognitive decline (PCD) represents a dual impairment of mobility and cognitive function in aging populations, significantly increasing risks of disability, dementia, and mortality.
Yi-Long Huang, Wei-Ju Chang, Chao-Hsiung Lin, Shu Zhang, Yukiko Nishita, Rei Otsuka, Wei-Ju Lee, Chih-Kuang Liang, Ming-Yueh Chou, Li-Ning Peng, Hidenori Arai, Luigi Ferrucci, Liang-Kung Chen   +12 more
doaj   +1 more source

Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study

Journal of Diabetes Research, 2018
Background. A prevalent side-effect of simvastatin is attenuated glucose homeostasis. The underlying mechanism is unknown, but impaired lipid metabolism may provide the link.
Steen Larsen, Andreas Vigelsø, Sune Dandanell, Clara Prats, Flemming Dela, Jørn Wulff Helge   +5 more
doaj   +1 more source

Healthy aging in the Americas [PDF]

Revista Panamericana de Salud Pública, 2021
Jarbas Barbosa da Silva Jr., John W. Rowe, Jose Ricardo Jauregui   +2 more
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source