Results 141 to 150 of about 960,492 (356)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AGE DYNAMIC OF THE MOTOR EVOKED POTENTIAL FROM THE TONGUE IN HEALTHY PERSONS

, 2021
В. Б. Войтенков, В. Н. Команцев, А. В. Климкин, Е. В. Екушева, Н. В. Скрипченко, М. А. Бедова   +5 more
openalex   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multidomain Healthy-Age Programme. Recomendations for Healthy Ageing: On Behalf of the Healthy-Age Network

, 2021
El envejecimiento es un proceso natural asociado a un declive que repercute en un mayor riesgo de padecer discapacidad física y cognitiva, y/o afección emocional y social. En consecuencia, diversos estudios muestran los múltiples beneficios de los programas de entrenamiento multicomponente.
Marcos Pardo, Pablo Jorge, González Gálvez, Noelia, Vaquero Cristóbal, Raquel, Sagarra Romero, Lucía, López Vivancos, Abraham, Velázquez Díaz, Daniel, Gea García, Gemma María, Ponce González, Jesús Gustavo, Esteban Cornejo, Irene, Jiménez Pavón, David, Carbonell Baeza, Ana   +10 more
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Laboratory blood test results beyond normal ranges could not be attributed to healthy aging

, 2018
Bożena Czarkowska‐Pączek, Aleksandra Wyczałkowska-Tomasik, Leszek Pączek   +2 more
openalex   +1 more source

The Distribution of PSA Age-Specific Profiles in Healthy Irish Men between 20 and 70 [PDF]

, 2012
Rowan G. Casey, Paul K. Hegarty, Ronan Conroy, Daniel Rea, M. Butler, R. Grainger, Ted McDermott, J. A. Thornhill   +7 more
openalex   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Nutritional status and dietary intake among Nigerian adolescent: a systematic review

BMC Public Health
Introduction The prevailing nutritional conditions and the triple challenge of malnutrition faced by adolescents have adverse consequences for both the present and future generations’ health and nutrition.
Hadiza Abdullahi Abubakar, Mohd Razif Shahril, Sumaiyah Mat   +2 more
doaj   +1 more source