Results 31 to 40 of about 18,175 (207)

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

The Skill of Requesting Clarification and Responding to the Request for Clarification in Children with Cochlear Implant [PDF]

̒Ilm-i Zabān
The strategy of conversational repair is one of the most important pragmatic skills, which includes requesting clarification and responding to the request for clarification.
Elnaz Rashed Chitgar, Reyhane Mohamadi, Sakineh Mohammad Zamani, Mohammad Hassan Torabi   +3 more
doaj   +1 more source

Public health and evidence-informed policy-making: The case of a commonly used herbicide

Scandinavian Journal of Work, Environment & Health, 2020
"Despite substantial evidence that Roundup weed killer is safe and non-carcinogenic if used properly, a federal judge last week appointed attorney Kenneth Feinberg to oversee court-mandated settlement talks between Bayer AG (the company that owns Roundup’
Harri Vainio
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

`Value of Primary Health Care` project: patient education in primary health care setting

International Journal of Integrated Care, 2019
Introduction: The main responsibility of health care entities is to improve public health and stimulate patients to take care of their own health. An inseparable element of health promotion is the health education.
Marika Guzek, Anna Kordowska, Damian Chaciak, Artur Prusaczyk, Paweł Żuk, Magdalena Bogdan, Sylwia Szafraniec-Burylo, Grzegorz Bukato, Barbara Kaczmarska, Małgorzata Gałązka-Sobotka   +9 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Foundation phase male teachers’ reflections in teaching of comprehensive sexuality education in the Eastern Cape province of South Africa

Perspectives in Education
Children in their childhood and teenage years can acquire either healthy or unhealthy lifestyles. Without proper guidance, unhealthy lifestyles (e.g.
Obakeng Kagola
doaj   +1 more source

Starting the Conversation

Voices in Bioethics, 2015
"You don’t seem to realize the fact that you’re white.” The voice on the line stung with derision, palpably piercing my senses more directly than the westward summer sun blanketing the balcony where I sat.
Randi Belisomo
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source