The PPARy ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARy in the subcutaneous adipose tissue [PDF]
, 2008 PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per fat cell. We investigated whether ligand availability for PPAR¿ is rate limiting in fat mass generation and substrate metabolism.
Bakker, A.H.F. +3 more
core +2 more sources
Dietary patterns, insulin sensitivity and inflammation in older adults. [PDF]
, 2012 Background/objectivesSeveral studies have linked dietary patterns to insulin sensitivity and systemic inflammation, which affect risk of multiple chronic diseases.
Anderson, AL +7 more
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Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity [PDF]
, 2018 Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure.
Costa, Rafael M. +3 more
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Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults
Diabetes, 2019 The ability to switch fuels for oxidation in response to changes in macronutrient composition of diet (metabolic flexibility) may be informative of individuals’ susceptibility to weight gain.
Brittany Begaye +7 more
semanticscholar +1 more source
Active: journal of physical education, sport, health and recreation, 2020 Hypertension is mostly associated with adulthood and old age with little attention on children. This study provided evidence of hypertension in healthy children and its association with body composition and aerobic capacity (VO2max). 266 healthy children
Aaron Azzu Tetteh, Monday Omoniyi Moses
doaj +1 more source
Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects [PDF]
, 2003 The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.
Feinle-Bisset, C. +3 more
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Current Therapeutic Research, 2014 Background: Cactus (Opuntia ficus-indica) fiber was shown to promote weight loss in a 3-month clinical investigation. As demonstrated by in vitro studies, cactus fiber binds to dietary fat and its use results in reduced absorption, which in turn leads to
Ralf Uebelhack, MD, PhD +4 more
doaj +1 more source
BMC Physiology, 2017 BackgroundObese individuals differ in their risk of developing metabolic and cardiovascular complications depending on fat distribution (subcutaneous versus visceral) and adipose tissue (AT) phenotype (hyperplasic versus hypertrophic). However, the exact
Kathrin Landgraf +7 more
semanticscholar +1 more source
High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
Science, 2021 Gut bugs and systemic disease risk What people eat has an immediate selective effect on the microbial populations resident in the gut. A high-fat diet is associated with the occurrence of microbes that catabolize choline and the accumulation of ...
Woongjae Yoo +18 more
semanticscholar +1 more source
Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents [PDF]
, 2016 AIM: To establish a threshold value for liver fat content between healthy children and those with non-alcoholic fatty liver disease (NAFLD) by using magnetic resonance imaging (MRI), with liver biopsy serving as a reference standard.
BEZZI, Mario +6 more
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