Results 71 to 80 of about 3,703,784 (349)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls

Gastroenterology Research and Practice, 2013
Background. Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls.
Niraj S. Patel, Michael R. Peterson, Grace Y. Lin, Ariel Feldstein, Bernd Schnabl, Ricki Bettencourt, Ekihiro Seki, Claude B. Sirlin, Rohit Loomba   +8 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Optimal mapping of joint faults into healthy joint velocity space for fault-tolerant redundant manipulators [PDF]

, 2011
redundant ...
Abdi, Abdi, Abdi, Anthony A. Maciejewski, Hamid Abdi, Roberts, Roberts, Saeid Nahavandi, Wu, Yakov Frayman, Zhao, Zhao, Zhao   +12 more
core   +3 more sources

Multidisciplinary lifestyle intervention in children and adolescents - results of the project GRIT (Growth, Resilience, Insights, Thrive) pilot study [PDF]

, 2020
Background: During childhood and adolescence leading behavioural risk factors for the development of cardiometabolic diseases include poor diet quality and sedentary lifestyle.
, Cohen, Felicity, Isenring, Elizabeth, Marshall, Skye, Mayr, Hannah L, Soenen, Stijn   +5 more
core   +1 more source

Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial

Gut, 2019
Objective To investigate whether diets differing in fat content alter the gut microbiota and faecal metabolomic profiles, and to determine their relationship with cardiometabolic risk factors in healthy adults whose diet is in a transition from a ...
Y. Wan, Fenglei Wang, Jihong Yuan, Jie Li, Dandan Jiang, Jingjing Zhang, Hao Li, Ruo-Huang Wang, Jun Tang, Tao Huang, Ju-Sheng Zheng, A. Sinclair, J. Mann, Duo Li   +13 more
semanticscholar   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Marketers’ Use Of Alternative Front-Of-Package Nutrition Symbols: An Examination Of Effects On Product Evaluations [PDF]

, 2017
How front-of-package (FOP) nutrition icon systems affect product evaluations for more and less healthful objective nutrition profiles is a critical question facing food marketers, consumers, and the public health community.
Andrews, J. Craig, Burton, Scot, Kees, Jeremy, Netemeyer, Richard G, Newman, Christopher L.   +4 more
core   +2 more sources

Trends in Dietary Carbohydrate, Protein, and Fat Intake and Diet Quality Among US Adults, 1999-2016.

Journal of the American Medical Association (JAMA), 2019
Importance Changes in the economy, nutrition policies, and food processing methods can affect dietary macronutrient intake and diet quality. It is essential to evaluate trends in dietary intake, food sources, and diet quality to inform policy makers ...
Zhilei Shan, C. Rehm, G. Rogers, Mengyuan Ruan, Dong D. Wang, F. Hu, D. Mozaffarian, F. Zhang, S. Bhupathiraju   +8 more
semanticscholar   +1 more source

Disentangling High Fat, Low Carb, and Healthy Aging [PDF]

Cell Metabolism, 2017
Dietary interventions are simple, non-invasive tools that can be utilized to improve health and lifespan. In this issue, Roberts et al. (2017) and Newman et al. (2017) reveal the physiological benefits of feeding mice ketogenic diets and suggest different underlying mechanisms that may promote healthy aging.
openaire   +2 more sources