Results 81 to 90 of about 3,703,784 (349)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Visceral Adiposity Index, Body Fat Index and Fat Mass In Patients with Chronic Renal Failure

Haseki Tıp Bülteni, 2020
Aim:The aim of this study was to investigate the level of visceral adiposity index (VAI), body fat index and fat mass in patients with chronic renal failure (CRF).Methods:A total of 231 subjects were enrolled, of which 83, 64 and 84 subjects were ...
Sema Kunt, Şakir Özgür Keşkek
doaj   +1 more source

The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial

Frontiers in Nutrition, 2023
IntroductionMetabolic flexibility (MetF) is the capacity of an organism to oxidate substrate according to substrate availability or demand. The mismatch of substrate availability and oxidation may cause ectopic fat accumulation in the muscle and the ...
Wei Huang, Wei Huang, Weiqi Ruan, Weiqi Ruan, Cuilan Huo, Yanyu Lin, Yanyu Lin, Tian Wang, Tian Wang, Xiangdi Dai, Xiangdi Dai, Haonan Zhai, Jiasheng Ma, Jingyi Zhang, Jingyi Zhang, Jin Lu, Jie Zhuang, Jie Zhuang   +17 more
doaj   +1 more source

Texture analysis of vertebral bone marrow using chemical shift encoding–based water-fat MRI:a feasibility study [PDF]

, 2019
Summary This feasibility study investigated the spatial heterogeneity of the lumbar vertebral bone marrow using chemical shift encoding–based water-fat MRI. Acquired texture features like contrast and dissimilarity allowed for differentiation of pre- and
Baum, T., Burian, E., Dieckmeyer, M., Diefenbach, M.N., Hedderich, D.M., Karampinos, D.C., Kirschke, J.S., Mookiah, M.R.K., Rohrmeier, A., Rummeny, E.J., Ruschke, S., Subburaj, K., Zimmer, C.   +12 more
core   +2 more sources

Metabolically healthy obesity: facts and fantasies.

Journal of Clinical Investigation, 2019
Although obesity is typically associated with metabolic dysfunction and cardiometabolic diseases, some people with obesity are protected from many of the adverse metabolic effects of excess body fat and are considered "metabolically healthy." However ...
Gordon I. Smith, B. Mittendorfer, S. Klein   +2 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Thyroid-associated Orbitopathy: Quantitative Evaluation of the Orbital Fat Volume and Edema Using IDEAL-FSE

European Journal of Radiology Open, 2019
Background and Purpose: To compare orbital quantitative data obtained by fast spin-echo iterative decomposition of water and fat with echo asymmetry and least-squares estimation (FSE-IDEAL) in patients with thyroid-associated orbitopathy (TAO) and ...
Yoko Kaichi, Keizo Tanitame, Hiroaki Terada, Hideki Itakura, Haruya Ohno, Masayasu Yoneda, Yuji Takahashi, Yuji Akiyama, Kazuo Awai   +8 more
doaj   +1 more source

Fat fraction quantification of lumbar spine: comparison of T1-weighted two-point Dixon and single-voxel magnetic resonance spectroscopy in diagnosis of multiple myeloma

Diagnostic and Interventional Radiology, 2020
PURPOSEWe aimed to investigate the value of T1-weighted two-point Dixon technique and single-voxel magnetic resonance spectroscopy (MRS) in diagnosis of multiple myeloma (MM) through quantifying fat content of vertebral marrow.METHODSA total of 30 MM ...
Xiao-Jiao Pei, Yu-Fei Lian, Yu-Chang Yan, Tao Jiang, Ai-Jun Liu, Qing-Lei Shi, Zhen-Yu Pan   +6 more
doaj   +1 more source

Fat Therapeutics: The Clinical Capacity of Adipose-Derived Stem Cells and Exosomes for Human Disease and Tissue Regeneration

Frontiers in Pharmacology, 2020
Fat grafting is a well-established surgical technique used in plastic surgery to restore deficient tissue, and more recently, for its putative regenerative properties.
L. Shukla, Yinan Yuan, R. Shayan, D. Greening, T. Karnezis   +4 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source