Results 111 to 120 of about 292,816 (279)

Healthy life expectancy : is there convergence in Europe?

, 2021
Para avançar nosso conhecimento sobre convergência em saúde global, este estudo empregou dados de 31 países europeus para testar a hipótese de convergência do uso de dados de expectativa de vida em saúde (HLE) de 2004 a 2016. A convergência foi examinada por meio de diferentes perspetivas na literatura.
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Older adults' beliefs about physician-estimated life expectancy: a cross-sectional survey

BMC Family Practice, 2006
Background Estimates of life expectancy assist physicians and patients in medical decision-making. The time-delayed benefits for many medical treatments make an older adult's life expectancy estimate particularly important for physicians.
Bynum Debra L, Amick Halle R, Lewis Carmen L, Kistler Christine E, Walter Louise C, Watson Lea C   +5 more
doaj   +1 more source

Assessing old-age long-term care using the concepts of healthy life expectancy and care duration: the new parameter "Long-Term Care-Free Life-Expectancy (LTCF)" [PDF]

Achieving old ages is also connected with prevalence of illness and long-term care. With the introduction of the statutory long-term care insurance in 1996 and the long-term care statistics in 1999 research data of about 2.3 million people receiving long-
Anne Schulz, Rembrandt D. Scholz
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metropolitan inequalities in health system resources and COVID-19 adjusted life expectancy among older adults in Mexico

Frontiers in Public Health
IntroductionThe mortality and morbidity consequences of the COVID-19 outbreak were concentrated among older adults. The health system response was critical to mitigating its negative effects, particularly through the redistribution of healthcare ...
Héctor García-Hernández, Héctor García-Hernández, Guillermo Salinas-Escudero, Marcela Agudelo-Botero, Hortensia Reyes-Morales   +4 more
doaj   +1 more source

Healthy life expectancy: comparison of OECD countries in 2001

Australian and New Zealand Journal of Public Health, 2003
Objectives: To compare average levels of population health for Australia and other OECD countries in 2001. Methods: Healthy life expectancies (HALE) for OECD countries for 2001 are based on analysis of mortality data for OECD countries, country‐specific ...
Colin D. Mathers, Christopher J.L. Murray, Joshua A. Salomon, Ritu Sadana, Ajay Tandon, Alan D. Lopez, Bedirhan Ustün, Somnath Chatterji   +7 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

In sickness and in Health? Dynamics of health and cohabitation in the United Kingdom [PDF]

, 2007
The purpose of this paper is to analyse the dynamics of cohabitation and functional impairments among older people. Our research has three main aims. Firstly, we want to analyse the effects of cohabitation on disability.
Karlsson, M., Mayhew, L., Rickayzen, B. D.   +2 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source