Results 91 to 100 of about 290,919 (288)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Issues and Challenges of Measurement of Health:Implications for Economic Research [PDF]

According to the human capital theory, health is a determinant of the economic development and should play a role in the fight against poverty. On the other side, the economic growth, by supplying better sanitation, water quality and hygiene, better ...
Martine AUDIBERT
core   +3 more sources

Would the elimination of obesity and smoking reduce U.S. racial/ethnic/nativity disparities in total and healthy life expectancy?

SSM: Population Health, 2019
Obesity and smoking are the two leading causes of preventable death and disability in the United States. Both of these health risks are socially patterned in ways that likely produce racial/ethnic/nativity disparities in total and healthy life expectancy.
Michelle L. Frisco, Jennifer Van Hook, Robert A. Hummer   +2 more
doaj   +1 more source

Demographic Change, Social Security Systems, and Savings [PDF]

In theory, improvements in healthy life expectancy should generate increases in the average age of retirement, with little effect on savings rates. In many countries, however, retirement incentives in social security programs prevent retirement ages from
David Canning, David E. Bloom, Michael Moore, Rick Mansfield   +3 more
core  

Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS) [PDF]

, 2017
Background: Little is known about how dependency levels have changed between generational cohorts of older people. We estimated years lived in different care states at age 65 in 1991 and 2011 and new projections of future demand for care.
Arthur, A., Baldwin, C., Barnes, L. E., Barnes, R., Brayne, C., Brayne, Carol, Comas-Herrera, A., Dening, T., Forster, G., Gao, L., Green, E., Harrison, S., Ince, P. G., Jagger, Carol, Kingston, Andrew, Matthews, Fiona E., McKeith, I. G., Parry, B., Pickett, J., Robinson, Louise, Stephan, B. C.M., Weller, R., Wharton, S., Wittenberg, Raphael, Wohland, Pia, Woods, B.   +25 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A model for geographical variation in health and total life expectancy [PDF]

This paper develops a joint approach to life and health expectancy based on 2001 UK Census data for limiting long term illness and general health status, and on registered death occurrences in 2001.
Peter Congdon
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Algorithm for decomposition of differences between aggregate demographic measures and its application to life expectancies, healthy life expectancies, parity-progression ratios and total fertility rates

Demographic Research, 2002
A general algorithm for the decomposition of differences between two values of an aggregate demographic measure in respect to age and other dimensions is proposed.
doaj  

Population-based estimates of healthy working life expectancy in China

BMC Geriatrics
Background Despite growing interest in population aging and extended working lives, little is known in developing countries about people’s quality of working life and their capacity to work for longer years when approaching retirement age.
Guogui Huang, Yao Pan, Yanan Luo
doaj   +1 more source