Results 91 to 100 of about 8,055,040 (281)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Population-based estimates of healthy working life expectancy in China

BMC Geriatrics
Background Despite growing interest in population aging and extended working lives, little is known in developing countries about people’s quality of working life and their capacity to work for longer years when approaching retirement age.
Guogui Huang, Yao Pan, Yanan Luo
doaj   +1 more source

Promoting the “Revitalization of Healthy Life Expectancy” with the Town of Anamizu

YAKUGAKU ZASSHI, 2019
The town of Anamizu in Housu District, Ishikawa Prefecture, in the northern part of the Noto Peninsula, has 8600 residents of whom 45.4% are 65 years or older, making it a region with an aging population. A project was launched to "make Anamizu a town known for the good health and long life" of its citizens.
Keigo, Miyamoto, Tamaki, Ozaki, Kumiko, Onishi, Hiroshi, Takehana, Kaori, Tonoda, Masamitsu, Hara   +5 more
openaire   +3 more sources

Algorithm for decomposition of differences between aggregate demographic measures and its application to life expectancies, healthy life expectancies, parity-progression ratios and total fertility rates [PDF]

A general algorithm for the decomposition of differences between two values of an aggregate demographic measure in respect to age and other dimensions is proposed.
Evgeny Andreev, Vladimir Shkolnikov, Alexander Z. Begun   +2 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Healthy life expectancy in Europe

, 2013
Each year since 2005, Eurostat has calculated life expectancy without activity limitations, known as"healthy life years". While life expectancy at age 65 increased by one year in the European Union between2005 and 2010, the years lived in poor perceived health decreased (by 0.5 years for men and 1.1 years for women)despite an increase in years with ...
Robine, Jean-Marie, Cambois, E
openaire   +2 more sources

Healthy life expectancy : is there convergence in Europe?

, 2021
Para avançar nosso conhecimento sobre convergência em saúde global, este estudo empregou dados de 31 países europeus para testar a hipótese de convergência do uso de dados de expectativa de vida em saúde (HLE) de 2004 a 2016. A convergência foi examinada por meio de diferentes perspetivas na literatura.
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

An integrated approach to cause-of-death analysis: cause-deleted life tables and decompositions of life expectancy [PDF]

This article integrates two methods that analyze the implications of various causes of death for life expectancy. One of the methods attributes changes in life expectancy to various causes of death; the other method examines the effect of removing deaths
Samuel Preston, Hiram Beltran-Sanchez, Vladimir Canudas-Romo   +2 more
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source