Results 61 to 70 of about 437,610 (188)

Can AI Moderate Online Communities? [PDF]

arXiv, 2023
The task of cultivating healthy communication in online communities becomes increasingly urgent, as gaming and social media experiences become progressively more immersive and life-like. We approach the challenge of moderating online communities by training student models using a large language model (LLM).
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Direct Healthy Life Expectancy Estimates from Life Tables with a Sullivan Extension. Bridging the Gap Between HALE and Eurostat Estimates [PDF]

arXiv, 2019
The analytic derivation of a more general model of survival-mortality and the estimation of a parameter bx related to the Healthy Life Years Lost (HLYL) is followed with the formulation of a computer program providing results similar to those of the World Health Organization for the Healthy Life Expectancy (HALE) and the corresponding HLYL estimates ...
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Estimating the Healthy Life Expectancy from the Health State Function of a Population in Connection to the Life Expectancy at Birth [PDF]

arXiv, 2012
Following our previous works on the health state of a population and the related health state function we proceed in developing a method to estimate the Healthy Life Expectancy in connection to the relative impact of the Mortality Area in the health state function graph.
arxiv  

Terrestrial Life in Light of the Copernican Principle [PDF]

arXiv, 2023
Although many solar systems have been discovered, only one example of life is known. Thus, terrestrial life represents merely one data point. Consequently, extrapolating from terrestrial life to life elsewhere in the galaxy and beyond is often seen as a limitation in the search for different forms of life.
arxiv  

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Verifying the HALE measures of the Global Burden of Disease Study: Quantitative Methods Proposed [PDF]

arXiv, 2015
To verify the Global Burden of Disease Study and the provided healthy life expectancy (HALE) estimates from the World Health Organization (WHO) we propose a very simple model based on the mortality {\mu}x of a population provided in a classical life table and a mortality diagram. We use the abridged life tables provided by WHO.
arxiv  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

A Method for Estimating the Total Loss of Healthy Life Years: Applications and Comparisons in UK and Scotland [PDF]

arXiv, 2012
We propose a method of estimating the Total Loss of Healthy Life Years based on the first exit time theory for a stochastic process, the resulting Health State Function and the Deterioration Function estimated as the curvature of the health state function. We have done many applications in UK and Scotland and Sweden supporting our theory.
arxiv