Results 231 to 240 of about 609,352 (314)

Age- and sex-specific reference values for CT-based low skeletal muscle quantity and quality in healthy living kidney donors. [PDF]

Front Physiol
Martin D, Dolce P, Hübner M, Zingg T, Fuks D, Venetz JP, Maier D, Matter M, Becce F.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acculturation and Health Status in the Children's Healthy Living Program in the Pacific Region. [PDF]

Int J Environ Res Public Health
Sparks KS, Fialkowski MK, Dela Cruz R, Grandinetti A, Wilkens L, Banna JC, Bersamin A, Paulino Y, Aflague T, Coleman P, Deenik J, Fleming T, Novotny R.   +12 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Is Exergaming a Viable Tool in the Fight against Childhood Obesity?

Journal of Obesity, 2014
Gary S. Goldfield, Jameason D. Cameron, Jean-Philippe Chaput   +2 more
doaj   +1 more source

Regular Physical Activity: A Key to Healthy Living and an Indispensable Pillar of Lifestyle Medicine. [PDF]

Am J Lifestyle Med
Rippe JM.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Dietary Micronutrient Intake and the Prevalence of Metabolic Conditions among Children from the United States-Affiliated Pacific Region in the Children's Healthy Living Program. [PDF]

Curr Dev Nutr
Seale LA, Yamanaka AB, Hammond K, Lim E, Wilkens LR, McFall P, Aflague TF, Coleman P, Fleming T, Shallcross L, Deenik J, Novotny R.   +11 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source