Results 131 to 140 of about 1,504,481 (331)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Editorial: The built environment and public health: New insights

open access: yesFrontiers in Public Health, 2023
Linchuan Yang   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Improving urban environment through public commitment toward the implementation of clean and healthy living behaviors

open access: yesPsychology Research and Behavior Management, 2017
Nurul Hartini, Atika Dian Ariana, Triana Kesuma Dewi, Afif Kurniawan Faculty of Psychology, Universitas Airlangga, Surabaya, Indonesia Background: Some parts of northern Surabaya are slum areas with dense populations, and the majority of ...
Hartini N   +3 more
doaj  

Habitatul tradiţional românesc - leagăn al dezvoltării durabile [PDF]

open access: yes, 2012
Romania by its folk tradition is a true open air museum, which still preserves, in most of the rural areas, living examples of the originality and perpetuity of the building techniques.
Cristina Chiţonu
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Lessons Learned From the Creating Active Communities and Healthy Environments Toolkit Pilot: A Qualitative Study

open access: yesEnvironmental Health Insights, 2019
The US Army Public Health Center developed the Creating Active Communities and Healthy Environments (CACHE) Toolkit to help military installations evaluate the quality of their built environments relative to healthy eating, physical activity, and tobacco-
Marissa M Shams-White   +6 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

he Health of the Economy as a Living Organism [PDF]

open access: yesTheoretical and Applied Economics, 2010
According to “the health of the common living whole”, economy is a living organism, part of the human society, with which it is integrated in our microcosm environment. As organic component of the living, economy has as a viability criterion of its sense
Constantin POPESCU, Cristina BURGHELEA
doaj  

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