Results 141 to 150 of about 1,153,162 (300)
Creating Social and Health Equity: Adopting an Alberta Social Determinants of Health Framework [PDF]
, 2005 This discussion paper highlights the well-documented social factors that influence our health. In a time when the Alberta government is looking for the best innovative ideas around health care, we suggest that a social determinants approach would lead to
Philip O'Hara
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Local Government Actions to Prevent Childhood Obesity [PDF]
, 2009 Offers guidance on policy and programmatic actions local governments can take, with community input, to promote healthy eating and physical activity and to ensure equal opportunities for healthy living in low-income neighborhoods.
Annina Catherine Burns +2 more
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Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Project ViTAL ViTAL (Vitality Through Active Living) Fijian project [PDF]
, 2018 Physical inactivity, along with other lifestyle-related health risk factors such as an unhealthy diet, is becoming increasingly prevalent in developing countries which face rapid economic and social development, urbanization and industrialization.
Longhurst, Glynis
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Preventing Obesity Among Preschool Children: How Can Child-Care Settings Promote Healthy Eating and Physical Activity? [PDF]
, 2011 Synthesizes research about current practices in, opportunities for, and promising strategies for promoting a healthy diet and regular physical activity in early childhood.
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Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source