Results 141 to 150 of about 1,148,470 (340)

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Beyond Health Care: New Directions to a Healthier America [PDF]

open access: yes, 2009
Outlines recommendations for governments, schools, healthcare providers, philanthropies, and others to collaborate on implementing feasible, evidence-based interventions that create healthier communities and address the needs of those most at ...

core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Active Living: Promoting Physical Activity through Healthy Environments

open access: yes, 2017
Rapid urbanization poses significant public health challenges. By designing activity-friendly environments, designers and planners canenable people to be physically active in their daily routines and shape fundamental aspects of health and well being.
openaire   +1 more source

Lifestyle Profile of Elderly Living with Non-communicable Disease in Bangkok and Surabaya [PDF]

open access: yes, 2019
Lifestyle is one of the underlying risk factor of non-communicable disease (NCD). Dietary habit and exercise pattern are two indicators of lifestyle. Elderly are prone to NCD due to increased age which being independent risk factor.
Artsanthia, J. (Jintana)   +1 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Cohort Profile: Growing Up in Wales: The Environments for Healthy Living study [PDF]

open access: yesInternational Journal of Epidemiology, 2015
Morgan, Kelly   +4 more
openaire   +6 more sources

Supporting Healthy Communities Through the American Recovery and Reinvestment Act of 2009 [PDF]

open access: yes, 2009
Calls on state and local policy makers to use stimulus funding to make neighborhoods conducive to and safe for physical activity, build healthier schools, improve access to healthy foods, and prevent disease in low-income, rural, and minority ...

core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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