Results 131 to 140 of about 9,073,327 (280)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Peran Sekolah Dasar dalam Menumbuhkembangkan Perilaku Hidup Bersih dan Sehat pada Siswa di MIN 6 Tangerang

Jurnal Humanitas: Katalisator Perubahan dan Inovator Pendidikan
Clean and Healthy Living Behaviour (PHBS) is one of the important efforts in instilling healthy living habits in elementary school students. However, studies on PHBS in schools generally focus more on the role of teachers or school health programs, so ...
Syifani Yasmin, Een Unaenah, Eka Yulyawan Kurniawan   +2 more
doaj   +1 more source

Healthy parks, healthy people, healthy tourism : the application of the ASEAN Healthy Tourism Standard to address the emerging threats from tourism at Ha Long Bay World Heritage Site, Vietnam

, 2010
This paper explores problems associated with the impacts of tourism on the health of people and the environment. ASEAN through UWS is developing the concept of ‘Healthy Tourism’ to protect and promote the health of tourists and local communities to turn ...
Bushell, Robyn (R7359), Powis, Brent
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

TNO’s unique reformulation strategy : Food Innovation Concepts

, 2013
Reducing salt, sugar and fats without loss of taste, texture and shelf life.
Blankestijn, J.
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Rapid Assessment of the School Nutrition Policy Environment In Select Caribbean Countries

, 2019
In direct response to the widening gap between political commitments and policy implementation - in September 2019, arising out of a regional multisectoral meeting, the HCC launched A Civil Society Call to Urgent Action for the Caribbean Region to ...
Healthy Caribbean Coalition
core   +1 more source