Results 151 to 160 of about 9,073,327 (280)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Healthy Farm to School Fundraising with Nourish Your Roots
, 2018 Nourish Your Roots (NYR) is a healthy farm-to-school fundraising program of Nourish NS designed to: support the Food and Nutrition Policy for Nova Scotia Schools; help sustain healthy food-related programming in schools; and support the whole, healthy ...
Melissa Stewart
core +1 more source
Design of a healthy living environment for older adults with low vision
, 2006 HB2006 : proceedings of the 8th international conference healthy buildings. Oliveira Fernandez, E. de; Gameiro da Silva, M.; Rosada Pinto, J. (red). ISBN 989-95067-1-0 2006 4-8 juni, Lissabon, Portugal, volume III, p.
Sinoo, M.M. +3 more
openaire +1 more source
Healthy Weight for Children (0-6 years) Framework (November 2018)
, 2018 TThe purpose of this framework is to provide a strategic direction for a national and sustainable approach to facilitating healthy weight and the prevention of obesity in children aged 0-6 years in Ireland (see Appendix 2 for profile by gender and age).
Cooney, Fionnuala +4 more
core
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Acta Biomedica Scientifica, 2013 The estimation of the total effect of the environment on immune-metabolic parameters of people living in industrial areas of Primorsky region was conducted.
T. I. Vitkina +2 more
doaj
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source