Results 171 to 180 of about 87,068,806 (201)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Building a public health infrastructure to support family caregivers of people with dementia. [PDF]

Gerontologist
Gaugler JE, Johnson E, Epstein-Lubow G, Parker L, Epps F, Millenbah A.   +5 more
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Latine mothers' conceptions of bien educado in U.S. Latine adolescents: Respect, humility, good manners, and consideration for others as Core aspects. [PDF]

J Res Adolesc
Cruz AM, Carlo G.
europepmc   +1 more source

The impact of the pilot reform of home and community-based elderly care services on the health of the elderly. [PDF]

BMC Public Health
Qiu H, Yang X, Zhu Y, Zhang Y.
europepmc   +1 more source

Braiding Knowledge Systems: Integrating Indigenous Wisdom and Sustainable Research for a Regenerative Future. [PDF]

ACS Sustain Chem Eng
Edgar-Webkamigad E, Rebek JL, Twiss MR, Antunes PM, Aubin I, Molina I, Barone JM, Jones A, Moores A.   +8 more
europepmc   +1 more source

Cognitive Testing in Spanish Older Adults: A Scoping Review. [PDF]

Geriatrics (Basel)
Sáez-González L, Martínez LA, Blázquez-Abellán G, de Lara JAC, Martinez-Garcia RM, Castro-Vázquez L.   +5 more
europepmc   +1 more source

Radical Imagination: An Afrofuturism and Creative Aging Program for Black Women's Brain Health and Wellness. [PDF]

Int J Environ Res Public Health
Hill-Jarrett TG, Jackson AJ, Amuiri A, Aguirre GA.   +3 more
europepmc   +1 more source

When family caregiving happens: life-course timing and health outcomes in later life. [PDF]

J Gerontol B Psychol Sci Soc Sci
Lee C, Glei DA, Park S, Brown CK, Weinstein M.   +4 more
europepmc   +1 more source