Results 181 to 190 of about 3,471 (216)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Cross-sectional trends in healthy lifestyles among the oldest-old in China, 1998-2018. [PDF]

BMC Geriatr
Bai R, Zhang H, Qi X, Jiang T, Deng Y, Gao X, Deng J, Yao Y, Mei Y.   +8 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Disparities in 2020 Life Expectancy by Race and Ethnicity in Hawai'i. [PDF]

Hawaii J Health Soc Welf
Wu YY, Ching L, Prieto C, Phillips MM, Braun KL.   +4 more
europepmc   +1 more source

What's in Your Heart? Development of a Culturally Grounded and Trauma-Informed Parenting Support Program with a Pacific Northwest Tribe. [PDF]

Int J Environ Res Public Health
Waters SF, Richardson M, Marris A, Harris F, Parker M.   +4 more
europepmc   +1 more source

Racialized Aging in the Context of Climate Extremes: Post-Flood Healthy Aging and Recovery Among Older Adults in Quilombola Communities of Southern Brazil. [PDF]

Int J Environ Res Public Health
Gutiérrez-Murillo RS, Grossi PK, Wagner Leandro GC, Grossi ML.   +3 more
europepmc   +1 more source

Health and well-being of children and adolescents living in the Kimberley region of Western Australia: a scoping review protocol. [PDF]

BMJ Open
Cannon L, Carter E, Davies J, Thomas S, Elliott EJ, Rice LJ.   +5 more
europepmc   +1 more source