Results 91 to 100 of about 2,201,996 (338)

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Subjective and objective vestibular changes that occur following paediatric cochlear implantation: systematic review and meta-analysis

Journal of Otolaryngology - Head and Neck Surgery, 2019
Objective Cochlear implantation can result in post-operative vestibular dysfunction of unknown clinical significance. The objective of this study was to characterize the presence, magnitude, and clinical significance of vestibular dysfunction that occurs
Michael Yong, Emily Young, Jane Lea, Hannah Foggin, Erica Zaia, Frederick K. Kozak, Brian D. Westerberg   +6 more
doaj   +1 more source

“Can you hear me now?”: Insurance Coverage for Hearing Benefits in the United States [PDF]

, 2015
Public and private insurance coverage for hearing benefits underscores the gaps in coverage for treating hearing loss in the U.S. The commodification of the hearing benefits sector of healthcare in this country has detrimental consequences for personal ...
Whipple, Reegan
core   +1 more source

Intralabyrinthine Vestibular Schwannoma Responsive to Intratympanic Gentamicin Treatment [PDF]

, 2017
Intralabyrinthine schwannoma (ILS) is a rare benign tumor that affects the ends of cochlear and vestibular nerves. In a majority of the cases, it occurs with unilateral progressive sensorineural hearing loss.
Barbara, Maurizio, Covelli, Edoardo, Filippi, Chiara, Marrone, V, Monini, Simonetta, Tarentini, S, Volpini, Luigi   +6 more
core   +1 more source

Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage

Advanced Science, EarlyView.
The schematic diagram illustrates the role of the recruitment of Gal3‐CaN‐Smurf1 complex in maintaining lysosomal membrane homeostasis upon damage. On the one hand, the Gal3‐CaN‐Smurf1 complex sequesters FLCN‐FNIPs to block the activation of RagC, where the active form RagC‐GDP is responsible for TFEB phosphorylation.
Qin Xia, Ziwan Liu, Gaoqing Feng, Wanting Xu, HuaHua Wang, Haihang Su, Jiaqian Li, Dan Liu, Jun Qu, Tonghui Yu, Lei Dong   +10 more
wiley   +1 more source

The effect of screen time on auditory processing and working memory skills in tweens (pre-adolescents)

The Egyptian Journal of Otolaryngology
Background This study investigates the impact of screen time on auditory processing and working memory in tweens, considering the subtle relationship proposed by the Goldilocks Hypothesis.
Saransh Jain, Rakesh Trinesh, Srikar Vijayasarthy, Sanjana S. Singh, Amuna Dangi, Chandni Jain   +5 more
doaj   +1 more source

Serum levels of retinol and other antioxidants for hearing impairment among Japanese older adults.

, 2009
BACKGROUND: The objective of this study was to assess the relation between serum levels of retinol and other antioxidants and hearing impairment in Japanese older adults.
Asakura, Keiko, Hosoda, Kanae, Iwasawa, Satoko, Kikuchi, Yuriko, Michikawa, Takehiro, Milojevic, Ai, Mizutari, Kunio, Nakano, Makiko, Nishiwaki, Yuji, Saito, Hideyuki, Takebayashi, Toru   +10 more
core   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Hearing voices, dissociation and the self: a functional-analytic perspective [PDF]

, 2016
Item does not contain fulltextIn the current paper, we review existing models of the aetiology of voice hearing. We summarise the argument and evidence that voice hearing is primarily a dissociative process, involving critical aspects of self. We propose
Barnes-Holmes, Yvonne, Dillon, Jacqui, Egger, Jos, McEnteggart, Ciara, Oliver, Joseph E   +4 more
core   +3 more sources