Results 111 to 120 of about 2,201,996 (338)

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

open access: yesAdvanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen   +9 more
wiley   +1 more source

Bio‐Inspired SA‐FA Bionic Dual Receptor Electronic Skin for Intelligent Gesture and Material Cognition Systems Enhanced by Static‐Dynamic Mutual Interaction

open access: yesAdvanced Science, EarlyView.
In this work, bionic dual receptor (BDR) e‐skin based on the iontronic and triboelectric effects is proposed, inspired by the slow‐adapting and fast‐adapting receptors. Motivated by intelligent software algorithms and high‐speed hardware circuits, the proposed intelligent autonomous material cognition system integrated with the EDB e‐skin can ...
Hao Li   +5 more
wiley   +1 more source

Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing

open access: yesAdvanced Science, EarlyView.
A next‐generation cytosine base editor (zTadCBE) and other variants are developed by combining the high‐efficiency (TadCBEa) and low‐indel (TadCBEMax) architectures, followed by the introduction of zebrafish‐optimized mutations (V82S, Q154R) in the TadA domain.
Wei Qin   +7 more
wiley   +1 more source

Outcomes of Cochlear Implantation in Patients with Far-Advanced Otosclerosis Who Had Previously Undergone Stapes Surgery

open access: yesJournal of International Advanced Otology
BACKGROUND: The aim was to assess the hearing outcomes in cochlear implant patients with far-advanced otosclerosis who had previously undergone stapes surgery. METHODS: We studied 17 implanted patients with far-advanced otosclerosis who had previously
Piotr H. Skarzynski   +7 more
doaj   +1 more source

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy

open access: yesAdvanced Science, EarlyView.
Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng   +4 more
wiley   +1 more source

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