Results 41 to 50 of about 762,269 (339)

Hearing in Ants [PDF]

Science, 1900
n ...
openaire   +3 more sources

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Nature, 2017
Although genetic factors contribute to almost half of all cases of deafness, treatment options for genetic deafness are limited. We developed a genome-editing approach to target a dominantly inherited form of genetic deafness.
Xue Gao, Yong Tao, Yong Tao, Yong Tao, Verónica Lamas, Mingqian Huang, Wei-Hsi Yeh, B. Pan, Yujuan Hu, Yujuan Hu, J. H. Hu, J. H. Hu, J. H. Hu, David B. Thompson, David B. Thompson, Y. Shu, Y. Shu, Yamin Li, Hongyang Wang, Shi-ming Yang, Qiaobing Xu, D. Polley, M. Liberman, W. Kong, J. R. Holt, Zheng-Yi Chen, David R. Liu, David R. Liu, David R. Liu   +28 more
semanticscholar   +1 more source

Overinterpretation of high throughput sequencing data in medical genetics: first evidence against TMPRSS3/GJB2 digenic inheritance of hearing loss

Journal of Translational Medicine, 2019
Background Hearing loss (HL) is the most common disability of human senses characterized by a great allelic heterogeneity. GJB2 and TMPRSS3 are two well-known HL genes typically underlying its monogenic form.
Monika Ołdak, Urszula Lechowicz, Agnieszka Pollak, Dominika Oziębło, Henryk Skarżyński   +4 more
doaj   +1 more source

Self-Rated Benefits of Auditory Performance after Bonebridge Implantation in Patients with Conductive or Mixed Hearing Loss, or Single-Sided Deafness

Life, 2022
The Bonebridge implant can be a satisfactory solution for patients with conductive or mixed hearing loss (CHL or MHL), or with single-sided deafness (SSD).
Anna Ratuszniak, Piotr H. Skarzynski, Elżbieta Gos, Henryk Skarzynski   +3 more
doaj   +1 more source

Sodium Thiosulfate for Protection from Cisplatin‐Induced Hearing Loss

New England Journal of Medicine, 2018
Background Cisplatin chemotherapy and surgery are effective treatments for children with standard‐risk hepatoblastoma but may cause considerable and irreversible hearing loss.
P. Brock, R. Maibach, M. Childs, K. Rajput, D. Roebuck, Michael J. Sullivan, V. Laithier, M. Ronghe, P. Dall'Igna, E. Hiyama, B. Brichard, J. Skeen, Elena M. Mateos, M. Capra, A. Rangaswami, M. Ansari, C. Rechnitzer, G. Veal, A. Covezzoli, L. Brugières, G. Perilongo, P. Czauderna, B. Morland, E. Neuwelt   +23 more
semanticscholar   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Trends in Health Care Costs and Utilization Associated With Untreated Hearing Loss Over 10 Years

JAMA Otolaryngology - Head and Neck Surgery, 2019
Importance Nearly 38 million individuals in the United States have untreated hearing loss, which is associated with cognitive and functional decline. National initiatives to address hearing loss are currently under way.
N. Reed, A. Altan, J. Deal, C. Yeh, Alexander D Kravetz, M. Wallhagen, F. Lin   +6 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

The hearing hippocampus

Progress in Neurobiology, 2022
The hippocampus has a well-established role in spatial and episodic memory but a broader function has been proposed including aspects of perception and relational processing. Neural bases of sound analysis have been described in the pathway to auditory cortex, but wider networks supporting auditory cognition are still being established.
Alexander James Billig, Meher Lad, William Sedley, Timothy D. Griffiths   +3 more
openaire   +4 more sources

Extended high-frequency hearing enhances speech perception in noise

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Understanding speech in noisy environments is an essential communication skill that varies widely between individuals and is poorly understood.
Lina Motlagh Zadeh, N. Silbert, Katherine Sternasty, D. Swanepoel, L. Hunter, D. Moore   +5 more
semanticscholar   +1 more source