Results 41 to 50 of about 777,793 (338)

Precision‐Optimised Post‐Stroke Prognoses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope, Howard Bowman, Rachel M. Bruce, Alex P. Leff, Cathy J. Price   +4 more
wiley   +1 more source

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Nature, 2017
Although genetic factors contribute to almost half of all cases of deafness, treatment options for genetic deafness are limited. We developed a genome-editing approach to target a dominantly inherited form of genetic deafness.
Xue Gao, Yong Tao, Yong Tao, Yong Tao, Verónica Lamas, Mingqian Huang, Wei-Hsi Yeh, B. Pan, Yujuan Hu, Yujuan Hu, J. H. Hu, J. H. Hu, J. H. Hu, David B. Thompson, David B. Thompson, Y. Shu, Y. Shu, Yamin Li, Hongyang Wang, Shi-ming Yang, Qiaobing Xu, D. Polley, M. Liberman, W. Kong, J. R. Holt, Zheng-Yi Chen, David R. Liu, David R. Liu, David R. Liu   +28 more
semanticscholar   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Sodium Thiosulfate for Protection from Cisplatin‐Induced Hearing Loss

New England Journal of Medicine, 2018
Background Cisplatin chemotherapy and surgery are effective treatments for children with standard‐risk hepatoblastoma but may cause considerable and irreversible hearing loss.
P. Brock, R. Maibach, M. Childs, K. Rajput, D. Roebuck, Michael J. Sullivan, V. Laithier, M. Ronghe, P. Dall'Igna, E. Hiyama, B. Brichard, J. Skeen, Elena M. Mateos, M. Capra, A. Rangaswami, M. Ansari, C. Rechnitzer, G. Veal, A. Covezzoli, L. Brugières, G. Perilongo, P. Czauderna, B. Morland, E. Neuwelt   +23 more
semanticscholar   +1 more source

Understanding Contributors of Resilience in Youth With Childhood‐Onset Systemic Lupus Erythematosus Through a Socioecological Lens: A Mixed‐Methods Study

Arthritis Care &Research, EarlyView.
Objective This study aimed to identify themes contributing to resilience in childhood‐onset systemic lupus erythematosus (cSLE), distinguish between profiles of resilience, and examine how they relate to underlying themes and patient characteristics. Methods We conducted a mixed‐methods study of 21 patients with cSLE aged 11 to 19 years at a Canadian ...
Isabella Zaffino, Louise Boulard, Joanna Law, Asha Jeyanathan, Lawrence Ng, Sandra Williams‐Reid, Kiah Reid, Angela Cortes, Eugene Cortes, Ashley Danguecan, Deborah M. Levy, Linda T. Hiraki, Andrea M. Knight   +12 more
wiley   +1 more source

The hearing hippocampus

Progress in Neurobiology, 2022
The hippocampus has a well-established role in spatial and episodic memory but a broader function has been proposed including aspects of perception and relational processing. Neural bases of sound analysis have been described in the pathway to auditory cortex, but wider networks supporting auditory cognition are still being established.
Alexander James Billig, Meher Lad, William Sedley, Timothy D. Griffiths   +3 more
openaire   +4 more sources

Degeneration of saccular hair cells caused by MITF gene mutation

Neural Development, 2019
Background Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss.
Yi Du, Li-li Ren, Qing-qing Jiang, Xing-jian Liu, Fei Ji, Yue Zhang, Shuo-long Yuan, Zi-Ming Wu, Wei-Wei Guo, Shi-Ming Yang   +9 more
doaj   +1 more source

Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss

Frontiers in Aging Neuroscience, 2021
Age-related hearing loss (ARHL) is the most common sensory deficit in aging society, which is accompanied by increased speech discrimination difficulties in noisy environments, social isolation, and cognitive decline.
Barbara Peixoto Pinheiro, Youssef Adel, Marlies Knipper, Marcus Müller, Hubert Löwenheim   +4 more
doaj   +1 more source

Prevalence of Hearing Loss by Severity in the United States.

American Journal of Public Health, 2016
OBJECTIVES To estimate the age- and severity-specific prevalence of hearing impairment in the United States. METHODS We conducted cross-sectional analyses of 2001 through 2010 data from the National Health and Nutrition Examination Survey on 9648 ...
A. Goman, F. Lin
semanticscholar   +1 more source

Ageism in Rheumatology: The Health Care Professional's Perspective

Arthritis Care &Research, EarlyView.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the health care professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact
Aaron P. Smith, Pooja M. Achanta, Jiha Lee, Namrata Singh, Una E. Makris   +4 more
wiley   +1 more source