Results 81 to 90 of about 777,793 (338)

Pragmatic Language Difficulties in Children with Specific Language Impairment – A Systematic Review

Journal of Child Language Acquisition and Development, 2021
Specific Language Impairment (SLI) is a developmental disorder wherein a child fails to acquire age-appropriate linguistic skills. The study attempted a systematic review of articles pertaining to pragmatics in children with SLI in the last decade.
Swapna Narayanan, Kavya Vijayan, Prashanth Prabhu P., Mekhala V. G., Animesh Barman   +4 more
doaj  

Subjective and objective vestibular changes that occur following paediatric cochlear implantation: systematic review and meta-analysis

Journal of Otolaryngology - Head and Neck Surgery, 2019
Objective Cochlear implantation can result in post-operative vestibular dysfunction of unknown clinical significance. The objective of this study was to characterize the presence, magnitude, and clinical significance of vestibular dysfunction that occurs
Michael Yong, Emily Young, Jane Lea, Hannah Foggin, Erica Zaia, Frederick K. Kozak, Brian D. Westerberg   +6 more
doaj   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

The effect of screen time on auditory processing and working memory skills in tweens (pre-adolescents)

The Egyptian Journal of Otolaryngology
Background This study investigates the impact of screen time on auditory processing and working memory in tweens, considering the subtle relationship proposed by the Goldilocks Hypothesis.
Saransh Jain, Rakesh Trinesh, Srikar Vijayasarthy, Sanjana S. Singh, Amuna Dangi, Chandni Jain   +5 more
doaj   +1 more source

Hearing loss and incident dementia.

Archives of Neurology, 2011
OBJECTIVE To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD). DESIGN Prospective study of 639 individuals who underwent audiometric testing and were dementia free in 1990 to 1994.
F. Lin, E. Metter, Richard O'Brien, S. Resnick, A. Zonderman, L. Ferrucci   +5 more
semanticscholar   +1 more source

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Hearing loss as a risk factor for dementia: A systematic review

Laryngoscope Investigative Otolaryngology, 2017
To review evidence of hearing loss as a risk factor for dementia.
R. Thomson, Priscilla Auduong, Alexander T. Miller, R. Gurgel   +3 more
semanticscholar   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Persistent Olfactory and Taste Dysfunction after COVID-19

Life
(1) Background: One of the possible symptoms of COVID-19 is a sudden loss of smell and taste. The main aim of the study was to evaluate the severity of post-COVID-19 olfactory dysfunction (OD).
Malgorzata Buksinska, Piotr Henryk Skarzynski, Danuta Raj-Koziak, Elzbieta Gos, Malgorzata Talarek   +4 more
doaj   +1 more source