Results 111 to 120 of about 958,822 (310)

Reversal of auditory cortical hyperexcitability and restoration of synaptic plasticity balance by GluN1-mediated photobiomodulation in noise-induced tinnitus

Brain Research Bulletin
Glutamate receptors regulate neuronal excitability and drive synaptic plasticity in the auditory cortex (AC), with aberrant activation or dysfunction contributing to tinnitus pathogenesis.
Zhixin Zhang, Xinmiao Xue, Dongdong He, Peng Liu, Chi Zhang, Yvke Jiang, Shuhan Lv, Li Wang, Hanwen Zhou, Weidong Shen, Shiming Yang, Fangyuan Wang   +11 more
doaj   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

An Interpretable, Data‐Driven, Hierarchical Multi‐Domain Fusion Framework for Classification and Motor Function Scoring in Chronic Ankle Instability

Advanced Science, EarlyView.
An AI‐enabled digital twin framework integrates wearable EMG sensing with hierarchical multi‐domain fusion to classify chronic ankle instability, distinguish clinically relevant subtypes, and generate continuous motor function scores. Clinically interpretable functional stratification and SHAP‐based biomarker analysis provide transparent decision ...
Tianle Jie, Datao Xu, Zhifeng Zhou, Bas Van Hooren, Huiyu Zhou, Yi Yuan, Xiangli Gao, Monèm Jemni, Liangliang Xiang, Meizi Wang, Justin Fernandez, Tibor J. Goda, Yaodong Gu   +12 more
wiley   +1 more source

Clinical validation of 4K three-dimensional exoscope system in stapedotomy: a retrospective cohort study

Frontiers in Surgery
PurposeTo evaluate the technical feasibility and ergonomic advantages of 4K three-dimensional exoscope systems (4K3D-ES) versus operative microscope (OM) in stapedotomy.MethodsA retrospective cohort analysis compared 140 consecutive stapedotomy ...
Chaoyue Zhao, Chaoyue Zhao, Chaoyue Zhao, Chaoyue Zhao, Chaoyue Zhao, Chaoyue Zhao, Bo Gao, Bo Gao, Bo Gao, Bo Gao, Bo Gao, Guojian Wang, Guojian Wang, Guojian Wang, Guojian Wang, Guojian Wang, Honglei Zhang, Xin Zhang, Wei Liu, Dongyi Han, Dongyi Han, Dongyi Han, Dongyi Han, Dongyi Han, Yongyi Yuan, Yongyi Yuan, Yongyi Yuan, Yongyi Yuan, Yongyi Yuan, Hang Shao, Pu Dai, Pu Dai, Pu Dai, Pu Dai, Pu Dai   +34 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

'Keeping in Touch': Using the internet in speech and language therapy

International Journal of Integrated Care, 2014
Helen M Poole, Sheena Round, Carolyn Lees, Ricky Wallace, Claire Bimson, Louise Simcock, Paul Fergus   +6 more
doaj   +3 more sources

Did you see it?

eLife
Cautious reporting choices can artificially enhance how well analyses of brain activity reflect conscious and unconscious experiences, making distinguishing between the two more challenging.
Ling Liu
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Experimental Demonstration of Temporally Aware Fault‐Tolerant Sensor Fusion Using Memristive Associative Learning

Advanced Electronic Materials, EarlyView.
In dynamic driving scenarios, the proposed approach ensures only temporally aligned sensor inputs to make driving decisions, preventing false activations. By enabling selective hardware‐level learning, it achieves fast, reliable responses under noisy conditions.
Kapil Bhardwaj, Ashfak Nehal, Dmitrii Semenov, Roman Sotner, Sayani Majumdar   +4 more
wiley   +1 more source

What Makes Adults With Hearing Impairment Take Up Hearing Aids or Communication Programs and Achieve Successful Outcomes?

, 2012
OBJECTIVES:Client involvement in health decision making, or shared decision making, is increasingly being advocated. For example, rehabilitation interventions such as hearing aids and communication programs can be presented as options to adults with ...
Worrall, Linda,, Ariane Laplante-Lévesque, Hickson, Louise,, Linda Worrall, Louise Hickson, Laplante-Lévesque, Ariane,   +5 more
core   +1 more source