Results 11 to 20 of about 124,361 (268)

Genetics of Hearing Impairment [PDF]

Genes, 2022
The inner ear is a complex structure at the cellular and molecular levels [...]
Kremer, H., Kremer, H., del Castillo, I.
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Genomics and Hearing Impairment [PDF]

Genome Research, 1999
Hearing impairment is clinically and genetically heterogeneous. There are >400 disorders in which hearing impairment is a characteristic of the syndrome, and family studies demonstrate that there are at least 30 autosomal loci for nonsyndromic hearing impairment.
B J, Keats, C I, Berlin
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Automatic Recognition of Auditory Brainstem Response Characteristic Waveform Based on Bidirectional Long Short-Term Memory

Frontiers in Medicine, 2021
Background: Auditory brainstem response (ABR) testing is an invasive electrophysiological auditory function test. Its waveforms and threshold can reflect auditory functional changes in the auditory centers in the brainstem and are widely used in the ...
Cheng Chen, Li Zhan, Xiaoxin Pan, Zhiliang Wang, Xiaoyu Guo, Handai Qin, Fen Xiong, Wei Shi, Min Shi, Fei Ji, Qiuju Wang, Ning Yu, Ruoxiu Xiao, Ruoxiu Xiao   +13 more
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Key Genes and Pathways Associated With Inner Ear Malformation in SOX10 p.R109W Mutation Pigs

Frontiers in Molecular Neuroscience, 2018
SRY-box 10 (SOX10) mutation may lead to inner ear deformities. However, its molecular mechanisms on inner ear development are not clear. In this work, the inner ear morphology was investigated at different embryonic stages of the SOX10 mutation miniature
Qing-Qing Hao, Liang Li, Wei Chen, Qing-Qing Jiang, Fei Ji, Wei Sun, Hong Wei, Wei-Wei Guo, Shi-Ming Yang   +8 more
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A hypothesis study on bionic active noise reduction of auditory organs

Military Medical Research, 2018
Background Noise exposure can lead to hearing loss and multiple system dysfunctions. As various forms of noise exist in our living environments, and our auditory organs are very sensitive to acoustic stimuli, it is a challenge to protect our hearing ...
Qing-Qing Jiang, Ning Yu, Shi-Ming Yang
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Cochlear morphology in the developing inner ear of the porcine model of spontaneous deafness

BMC Neuroscience, 2018
Background Auditory function and cochlear morphology have previously been described in a porcine model with spontaneous WS2-like phenotype. In the present study, cochlear histopathology was further investigated in the inner ear of the developing ...
Wei Chen, Qing-Qing Hao, Li–Li Ren, Wei Ren, Hui-sang Lin, Wei-Wei Guo, Shi-Ming Yang   +6 more
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Generation of a human induced pluripotent stem cell line (CPGHi001-A) from a hearing loss patient with the TMC1 p.M418K mutation

Stem Cell Research, 2020
By using a nonintegrating plasmid delivery system, we generated induced pluripotent stem cells (iPSCs) from the urine cells of a male patient from the family carrying the TMC1 p.M418K mutation. This mutation is homologous to that in Beethoven mice, which
Hongyang Wang, Kaiwen Wu, Jing Guan, Qiuju Wang   +3 more
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NT5E upregulation in head and neck squamous cell carcinoma: A novel biomarker on cancer-associated fibroblasts for predicting immunosuppressive tumor microenvironment

Frontiers in Immunology, 2022
Despite tremendous progress made in the diagnosis and managements, head and neck squamous cell carcinoma (HNSC) remains a global medical dilemma with dismal clinical prognosis and high mortality.
Xue-min Chen, Xue-min Chen, Yu-yang Liu, Yu-yang Liu, Bing-yan Tao, Bing-yan Tao, Xin-miao Xue, Xin-miao Xue, Xin-xin Zhang, Lin-lin Wang, Hui Zhong, Hui Zhong, Jun Zhang, Shi-ming Yang, Qing-qing Jiang   +14 more
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Analysis of the genotype–phenotype correlation of MYO15A variants in Chinese non-syndromic hearing loss patients

BMC Medical Genomics, 2022
Background Mutations in the MYO15A gene are a widely recognized cause of autosomal recessive non-syndromic sensorineural hearing loss (NSHL) globally.
Ying Fu, Shasha Huang, Xue Gao, Mingyu Han, Guojian Wang, Dongyang Kang, Yongyi Yuan, Pu Dai   +7 more
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Gene4HL: An Integrated Genetic Database for Hearing Loss

Frontiers in Genetics, 2021
Hearing loss (HL) is one of the most common disabilities in the world. In industrialized countries, HL occurs in 1–2/1,000 newborns, and approximately 60% of HL is caused by genetic factors.
Shasha Huang, Shasha Huang, Shasha Huang, Guihu Zhao, Guihu Zhao, Jie Wu, Jie Wu, Jie Wu, Kuokuo Li, Kuokuo Li, Qiuquan Wang, Qiuquan Wang, Qiuquan Wang, Ying Fu, Ying Fu, Ying Fu, Honglei Zhang, Honglei Zhang, Honglei Zhang, Qingling Bi, Qingling Bi, Qingling Bi, Xiaohong Li, Xiaohong Li, Xiaohong Li, Weiqian Wang, Weiqian Wang, Weiqian Wang, Chang Guo, Chang Guo, Chang Guo, Dejun Zhang, Dejun Zhang, Dejun Zhang, Lihua Wu, Lihua Wu, Lihua Wu, Xiaoge Li, Xiaoge Li, Xiaoge Li, Huiyan Xu, Huiyan Xu, Huiyan Xu, Mingyu Han, Mingyu Han, Mingyu Han, Xin Wang, Chen Lei, Xiaofang Qiu, Yang Li, Jinchen Li, Jinchen Li, Pu Dai, Pu Dai, Pu Dai, Yongyi Yuan, Yongyi Yuan, Yongyi Yuan   +57 more
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