Results 41 to 50 of about 3,227,749 (300)

Recent preclinical and clinical advances in gene therapy for hereditary hearing loss

Molecules and Cells
: Hereditary hearing loss is a genetically heterogeneous condition that affects millions of people worldwide and has limited curative treatment options.
Seung Hyun Jang, Hyeong Gi Song, Jinsei Jung, Heon Yung Gee   +3 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Risk factors for hearing loss in children: a systematic literature review and meta-analysis protocol

Systematic Reviews, 2019
Background Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these negative effects.
Bénédicte Vos, Dorie Noll, Marie Pigeon, Marlene Bagatto, Elizabeth M. Fitzpatrick   +4 more
doaj   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs

, 2019
Purpose: Proper interpretation of genomic variants is critical to successful medical decision making based on genetic testing results. A fundamental prerequisite to accurate variant interpretation is the clear understanding of the clinical validity of ...
Kevin T. Booth, Siegert, Rebecca K, Xue Zhong Liu, Wendy Low, Jeffrey Holt, Neha Bhatia, Morag Lewis, Yu Lu, Marina T. DiStefano, Tan Yuen Ming, Duzkale, Hatice, Jaclyn Murray, Duzkale, H., Alex Chapin, Lilian Downie, Tayoun, Ahmad N Abou, Yasmin Bylstra, Hemphill, Sarah E., Brandon J. Cushman, Azaiez, H., Wenying Zhang, Thomas Friedman, Shen, Jun, Jasmine Goh, Hui-Jun Yuan, Grant, A.R., Karen Avraham, Amr, Sami S, DiStefano, Marina T., Kanika Jain, Hemphill, Sarah E, Hela Azaiez, Minjie Luo, Arti Pandya, Nicole Boczek, Rachel Burt, Un-Kyung Kim, Oza, Andrea M, Oza, A.M., Andrew R. Grant, Hatice Duzkale, Schimmenti, Lisa A, Booth, K.T., Oza, Andrea M., Andrew J. Griffith, Cushman, B.J., Shen, J., Ian Krantz, DiStefano, Marina T, Ignacio del Castillo, Matsunaga, T., Cynthia Morton, Elizabeth Black-Zeigelbein, Hannie Kremer, Guy Van Camp, DiStefano, M.T., Booth, Kevin T, Chapin, Alex, Tayoun, A.N.A., Schimmenti, L.A., Heidi L. Rehm, Matsunaga, Tatsuo, Madeline Y. Hughes, Keijan Zhang, Sonia Abdelhak, Lim Jiin Ying, Jun Shen, Amr, S.S., Ahmad N. Abou Tayoun, Funda Elif Suer, Rehm, Heidi L, John Alexander, Byung Yoon Choi, Amy Hernandez, Sarah E. Hemphill, Saber Masmoudi, Kenna, M., Hemphill, S.E., Hughes, M.Y., Suzanne Leal, Donglin Bai, Zippora Brownstein, Mustafa Tekin, Grant, Andrew R, et al., Shin-Ichi Usami, Tekin, M., Rebecca K. Siegert, Tatsuo Matsunaga, Zhang, W., Margaret Kenna, Kiyomitsu Nara, Saumya Shekhar Jamuar, Kazuki Yamazawa, Matías Morín, Rehm, H.L., Siegert, R.K., Sylvia Kam Pei-Rong, Andrea M. Oza, Richard J.H. Smith, Cushman, Brandon J, Tekin, Mustafa, Kenna, Margaret, Lisa A. Schimmenti, Sami S. Amr, Miguel Angel Moreno-Pelayo, Azaiez, Hela, Anne Giersch, Kremer, J.M.J., Zhang, Wenying, Van Camp, Guy, Makoto Hosoya, Hideki Mutai, Hughes, Madeline Y, Chapin, A., John Greinwald   +115 more
core   +2 more sources

Biallelic variants of SEMA3F are associated with nonsyndromic hearing loss

Molecules and Cells
: It is crucial to manage hearing loss and its associated public health impacts. In this study, we aimed to understand the role of Sema3f in the development and maintenance of the auditory system. Inner ear-specific Sema3f knockout mice exhibited hearing
Sun Young Joo, Hyehyun Min, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Ho Lee, Kyu Min Kim, Je Kyung Seong, Jae Young Choi, Jinsei Jung, Jinwoong Bok, Heon Yung Gee   +11 more
doaj   +1 more source

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Journal of Otolaryngology - Head and Neck Surgery, 2017
Background Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure tone threshold testing.
Trung N. Le, Louise V. Straatman, Jane Lea, Brian Westerberg   +3 more
doaj   +1 more source

Word Recognition and Learning: Effects of Hearing Loss and Amplification Feature [PDF]

, 2017
: Two amplification features were examined using auditory tasks that varied in stimulus familiarity. It was expected that the benefits of certain amplification features would increase as the familiarity with the stimuli decreased.

core   +1 more source

Behavioral Evaluation of 3 Smartphone-Based Hearing Aid Apps for Patients with Mild Hearing Loss: An Exploratory Pilot Study

, 2022
BACKGROUND: The aim of this study was to evaluate the behavioral performance of a selection of currently available hearing aid apps in patients with mild hearing loss. METHODS: We investigated 3 user-friendly hearing aid apps (EarMachine, Sound Amplifier,
Ho Lee, Jun, Jun Ho Lee, Oh, Seung-Ha, Nguyen, Willy, Willy Nguyen, Koo, Miseung, Lee, Jun Ho, Moo Kyun Park, Seung-Ha Oh, Miseung Koo, Kyun Park, Moo   +10 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source