Results 41 to 50 of about 3,081,609 (300)

Bone-anchored hearing aids for people with bilateral hearing impairment: a systematic review [PDF]

, 2011
BACKGROUND: Bone-anchored hearing aids (BAHAs) are indicated for people with conductive or mixed hearing loss who can benefit from amplification of sound.
Sheehan, P.Z., Clegg, A.J., Colquitt, J.L., Mitchell, T.E., T.E. Mitchell, A.J. Clegg, P.Z. Sheehan, D.M. Baguley, Loveman, E., D.W. Proops, P. Harris, J. Jones, Harris, P., Welch, K., K. Welch, J.L. Colquitt, Jones, J., Baguley, D.M., Proops, D.W., E. Loveman   +19 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Risk factors for hearing loss in children: a systematic literature review and meta-analysis protocol

Systematic Reviews, 2019
Background Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these negative effects.
Bénédicte Vos, Dorie Noll, Marie Pigeon, Marlene Bagatto, Elizabeth M. Fitzpatrick   +4 more
doaj   +1 more source

Molecular biology of hearing [PDF]

, 2012
The inner ear is our most sensitive sensory organ and can be subdivided into three functional units: organ of Corti, stria vascularis and spiral ganglion.
Diensthuber, M, Stöver, T, Diensthuber, Marc, Stöver, Timo   +3 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Biallelic variants of SEMA3F are associated with nonsyndromic hearing loss

Molecules and Cells
: It is crucial to manage hearing loss and its associated public health impacts. In this study, we aimed to understand the role of Sema3f in the development and maintenance of the auditory system. Inner ear-specific Sema3f knockout mice exhibited hearing
Sun Young Joo, Hyehyun Min, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Ho Lee, Kyu Min Kim, Je Kyung Seong, Jae Young Choi, Jinsei Jung, Jinwoong Bok, Heon Yung Gee   +11 more
doaj   +1 more source

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Journal of Otolaryngology - Head and Neck Surgery, 2017
Background Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure tone threshold testing.
Trung N. Le, Louise V. Straatman, Jane Lea, Brian Westerberg   +3 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review

Journal of Otology
The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated.
Jing-Ying Guo, Jun-Yi Xu, Shu-Sheng Gong, Guo-Peng Wang   +3 more
doaj   +1 more source

Luetic hearing loss [PDF]

The Laryngoscope, 1977
AbstractLuetic hearing loss has been noted with increasing frequency in recent years. Four cases of luetic hearing loss seen at Walter Reed General Hospital from 1974 to 1975 are presented and discussed. Symptoms and pathology of luetic involvement of the inner ear are also presented.
R T, Wong, M L, Lepore, G R, Burch, R L, Henderson   +3 more
openaire   +2 more sources