Results 61 to 70 of about 226,514 (268)
A novel mutation in COL1A1 causing osteogenesis imperfecta/hearing loss
, 2023 Ti-Ti Pan +5 more
openalex +1 more source
Advanced Science, EarlyView.This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun +15 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen +9 more
wiley +1 more source
National representative analysis of unilateral hearing loss and hearing aid usage in South Korea.
PLoS ONE, 2020 A definitive study on the prevalence of adult unilateral hearing loss and hearing aid rehabilitation is lacking in Korea. The purpose of our study was to investigate the prevalence of adult unilateral hearing loss and the factors associated with hearing ...
Se A Lee +4 more
doaj +1 more source
BROAD‐NESS Uncovers Dual‐Stream Mechanisms Underlying Predictive Coding in Auditory Memory Networks
Advanced Science, EarlyView.BROADband Network Estimation via Source Space (BROAD‐NESS) is a flexible analytical pipeline for identifying large‐scale brain networks from event‐related, source‐reconstructed MEG data, with a focus on auditory predictive and memory processes. BROAD‐NESS integrates a suite of complementary tools, including PCA‐based decomposition, phase space, and ...
Leonardo Bonetti +8 more
wiley +1 more source
Advanced Science, EarlyView.This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley +1 more source
Advanced Science, EarlyView.Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen +9 more
wiley +1 more source
Ultrasensitive Diamond Cantilever‐Based Optical Microphone
Advanced Science, EarlyView.The first demonstration that high quality diamond cantilevers function as high‐sensitivity acoustic transducers is reported, combining CVD diamond cantilevers and an extrinsic Fabry‐Perot optical configuration. High transduction efficiency yields record sensitivity (51.5 VPa−1) and MDP (0.018 µPa/Hz$\rm {\sqrt {Hz}}$), enabling durable, low‐noise ...
Shen Tian +8 more
wiley +1 more source
Advanced Science, EarlyView.This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen +7 more
wiley +1 more source