Results 51 to 60 of about 191,553 (318)

Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss

open access: yesMolecular Therapy: Methods & Clinical Development, 2021
There is growing attention and effort focused on treating the root cause of sensorineural hearing loss rather than managing associated secondary characteristic features.
Kamakshi Bankoti   +5 more
doaj   +1 more source

Toward Optogenetic Hearing Restoration

open access: yesAnnual Review of Neuroscience
The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical stimulation of the auditory nerve, the broad spread of current from each electrode acts as a bottleneck that limits the transfer of sound frequency information ...
Huet, Antoine   +3 more
openaire   +3 more sources

Virally mediated Kcnq1 gene replacement therapy in the immature scala media restores hearing in a mouse model of human Jervell and Lange‐Nielsen deafness syndrome

open access: yesEMBO Molecular Medicine, 2015
Mutations in the potassium channel subunit KCNQ1 cause the human severe congenital deafness Jervell and Lange‐Nielsen (JLN) syndrome. We applied a gene therapy approach in a mouse model of JLN syndrome (Kcnq1−/− mice) to prevent the development of ...
Qing Chang   +7 more
doaj   +1 more source

Middle Ear Salivary Choristoma: A Rare Case Report and Update on Congenital Associations, Facial Nerve Involvement, and Treatment Strategies

open access: yesCase Reports in Otolaryngology, 2020
Salivary gland choristoma is an extremely rare middle ear mass and is hypothesized to be caused by second branchial arch developmental anomalies. We present a 14-year-old girl with Dandy–Walker syndrome and conductive hearing loss. Middle ear exploration
Allen Young, Lauran Evans, Matthew Ng
doaj   +1 more source

Sudden Bilateral Sensorineural Hearing Loss Secondary to Cerebral Venous Thrombosis [PDF]

open access: yesIranian Journal of Otorhinolaryngology, 2018
Introduction: Sudden sensorineural hearing loss (SSNHL) is an important otological emergency. Up to 90% of the cases are idiopathic. Cerebral venous thrombosis (CVT) is an extremely rare identifiable cause as it only represents 0.5% of all strokes ...
Muhammad-Nu’aim Ishak   +2 more
doaj   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen   +6 more
wiley   +1 more source

Bioinspired Materials, Designs, and Manufacturing Strategies for Advanced Impact‐Resistant Helmets

open access: yesAdvanced Engineering Materials, EarlyView.
This review explores how bioinspired materials, structures, and manufacturing strategies transform helmet design to achieve enhanced impact resistance. Drawing inspiration from nacre, porcupine quills, beetle exoskeletons, and skull architectures, it highlights advances in auxetic lattices, nanocomposites, and functionally graded foams.
Joseph Schlager   +4 more
wiley   +1 more source

The ADA Amendments Act of 2008 [PDF]

open access: yes, 2008
The goal of the Americans with Disabilities Act (ADA) was to create a civil rights law protecting people with disabilities from discrimination on the basis of their disabilities.
Barry, Kevin   +2 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

Intrinsically Soft Printed Electronics for Digitally Augmented Human Sensing and Vision

open access: yesAdvanced Functional Materials, EarlyView.
This work introduces a class of highly functional, multilayer flexible and stretchable circuits capable of digitally augmenting human sensing and vision. Studies in multi‐material soft composite inks yielded a formulation that enables overpass printing, self‐healing, and high‐resolution functionality.
Nathan Zavanelli   +7 more
wiley   +1 more source

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