Results 41 to 50 of about 952,675 (273)

A CRISPR Way to Restore Hearing [PDF]

New England Journal of Medicine, 2018
Preserving Beethoven’s Hearing Researchers have employed a precise means of genetic editing, called CRISPR-Cas9, to “erase” a pathogenic variant that causes hearing loss in a mouse model termed “Beethoven.”
openaire   +2 more sources

Effect of COVID-19 on Individuals with Hearing Impairment in India [PDF]

Journal of Clinical and Diagnostic Research, 2020
COVID-19 has proven to be pandemic and affecting the day to day life of normal individuals. However, individuals with disability, especially with hearing impairment face even more difficulty.
Abishek Umashankar, Prashanth Prabhu
doaj   +1 more source

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Frontiers in Neuroscience, 2023
BackgroundThe electrical cochlear implant (eCI) partially restores hearing in individuals affected by profound hearing impairment (HI) or deafness. However, the limited resolution of sound frequency coding with eCIs limits hearing in daily situations ...
Victoria Hunniford, Victoria Hunniford, Robert Kühler, Bettina Wolf, Bettina Wolf, Bettina Wolf, Daniel Keppeler, Nicola Strenzke, Nicola Strenzke, Nicola Strenzke, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +14 more
doaj   +1 more source

Virally mediated Kcnq1 gene replacement therapy in the immature scala media restores hearing in a mouse model of human Jervell and Lange‐Nielsen deafness syndrome

EMBO Molecular Medicine, 2015
Mutations in the potassium channel subunit KCNQ1 cause the human severe congenital deafness Jervell and Lange‐Nielsen (JLN) syndrome. We applied a gene therapy approach in a mouse model of JLN syndrome (Kcnq1−/− mice) to prevent the development of ...
Qing Chang, Jianjun Wang, Qi Li, Yeunjung Kim, Binfei Zhou, Yunfeng Wang, Huawei Li, Xi Lin   +7 more
doaj   +1 more source

Making the Case for Research on Disease-Modifying Treatments to Tackle Post-lingual Progressive Sensorineural Hearing Loss

Frontiers in Neurology, 2020
Hearing loss not only has a significant impact on the quality of life of patients and society, but its correlation with cognitive decline in an aging population will also increase the risk of incident dementia. While current management of hearing loss is
Vincent Van Rompaey, Vincent Van Rompaey
doaj   +1 more source

μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve

EMBO Molecular Medicine, 2020
Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them.
Alexander Dieter, Eric Klein, Daniel Keppeler, Lukasz Jablonski, Tamas Harczos, Gerhard Hoch, Vladan Rankovic, Oliver Paul, Marcus Jeschke, Patrick Ruther, Tobias Moser   +10 more
doaj   +1 more source

Signal processing and stimulation potential within the ascending auditory pathway: a review

Frontiers in Neuroscience, 2023
The human auditory system encodes sound with a high degree of temporal and spectral resolution. When hearing fails, existing neuroprosthetics such as cochlear implants may partially restore hearing through stimulation of auditory neurons at the level of ...
Alexandra E. Quimby, Kimberly Wei, Dayo Adewole, Steven Eliades, D. Kacy Cullen, D. Kacy Cullen, Jason A. Brant, Jason A. Brant   +7 more
doaj   +1 more source

A local rehabilitation service for children with hearing loss [PDF]

Наука и инновации в медицине, 2021
Objectives to discuss the issues of inter-disciplinary cooperation for improvement the pediatric audiological care using modern technologies for hearing restoration. Material and methods.
Gaziz Sh. Tufatulin, Inna V. Koroleva
doaj   +1 more source

Lichen planus of the external auditory canal: Treatment options and review of literature

Clinical Case Reports, 2020
Medical topic therapies can relieve symptoms associated with lichen planus of external auditory canal. Further, bone‐anchored hearing devices represent an optimal solution for hearing restoration in otic lichen planus.
Francesco Lazzerini, Luca Bruschini, Stefano Berrettini, Andrea De Vito, Francesca Forli   +4 more
doaj   +1 more source

Pilot Chronic Evaluation of a Slanted Electrode Array as an Auditory Nerve Implant

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Objective: The purpose of this paper is to present a chronic, preclinical, pilot study of a multi-electrode auditory nerve implant. To date, the most successful auditory neuroprosthesis is the cochlear implant, but these devices have known limitations ...
W. Mitchel Thomas, Richard K. Gurgel, Loren Rieth, Inderbir Sondh, Hubert H. Lim, Meredith E. Adams, Moritz Leber, Joseph D. Crew, Florian Solzbacher, David J. Warren   +9 more
doaj   +1 more source