Results 71 to 80 of about 191,553 (318)

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Autosomal Recessive Non-Syndromic Deafness: Is AAV Gene Therapy a Real Chance?

Audiology Research
The etiology of sensorineural hearing loss is heavily influenced by genetic mutations, with approximately 80% of cases attributed to genetic causes and only 20% to environmental factors.
Davide Brotto, Marco Greggio, Cosimo De Filippis, Patrizia Trevisi   +3 more
doaj   +1 more source

Audiometric Findings in Senior Adults of 80 Years and Older

Frontiers in Psychology, 2022
ObjectiveTo examine hearing thresholds in senior adults of 80 years and older and compare this data to the current ISO 7029 reference values.DesignA descriptive, prospective study testing pure-tone and speech audiometry in senior adults participating in ...
Kaat De Raedemaeker, Ina Foulon, Roberta Vella Azzopardi, Elke Lichtert, Ronald Buyl, Vedat Topsakal, Ingo Beyer, Ingo Beyer, Ivan Bautmans, Olaf Michel, Frans Gordts   +10 more
doaj   +1 more source

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

A retrospective comparative study of endoscopic and microscopic Tympanoplasty

Journal of Otolaryngology - Head and Neck Surgery, 2018
Background This study compares endoscopic and microscopic tympanoplasty for the treatment of chronic otitis media (COM) without cholesteatoma. Methods This retrospective study included 153 ears (139 patients) treated surgically (endoscopic or microscopic
Ying-Chieh Hsu, Chin-Lung Kuo, Tzu-Chin Huang   +2 more
doaj   +1 more source

Perceptual learning of interrupted speech. [PDF]

PLoS ONE, 2013
The intelligibility of periodically interrupted speech improves once the silent gaps are filled with noise bursts. This improvement has been attributed to phonemic restoration, a top-down repair mechanism that helps intelligibility of degraded speech in ...
Michel Ruben Benard, Deniz Başkent
doaj   +1 more source

Aging, Cognitive Decline and Hearing Loss: Effects of Auditory Rehabilitation and Training with Hearing Aids and Cochlear Implants on Cognitive Function and Depression among Older Adults [PDF]

, 2016
A growing interest in cognitive effects associated with speech and hearing processes is spreading throughout the scientific community essentially guided by evidence that central and peripheral hearing loss is associated with cognitive decline.
Benatti, Alice, Bovo, Roberto, Castiglione, Alessandro, Favaro, Diego, Gabelli, Carlo, Martini, Alessandro, Padoan, Elisa, Pagliaro, Michela, Severi, Daniele, Vallesi, Antonino, Velardita, Carmelita   +10 more
core   +1 more source

Conductive Hearing Loss and Bone Conduction Devices: Restored Binaural Hearing? [PDF]

, 2011
An important aspect of binaural hearing is the proper detection of interaural sound level differences and interaural timing differences. Assessments of binaural hearing were made in patients with acquired unilateral conductive hearing loss (UCHL, n = 11) or congenital UCHL (n = 10) after unilateral application of a bone conduction device (BCD), and in ...
Agterberg, M.J.H., Hol, M.K.S., Cremers, C.W.R.J., Mylanus, E.A.M., Opstal, A.J. van, Snik, A.F.M.   +5 more
openaire   +3 more sources

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source