Results 51 to 60 of about 3,812,853 (308)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

O-CCR: oriented cervical canal region detection framework toward cervical change assessment in transvaginal ultrasound

open access: yesBMC Medical Imaging
Background The cervix undergoes morphological and structural changes during pregnancy in preparation for delivery. Assessing the progression of these changes using transvaginal ultrasound (TVUS) is crucial for preterm birth prediction.
Minseo Hwangbo   +6 more
doaj   +1 more source

Computer vision in surgery: from potential to clinical value

open access: yesnpj Digital Medicine, 2022
Hundreds of millions of operations are performed worldwide each year, and the rising uptake in minimally invasive surgery has enabled fiber optic cameras and robots to become both important tools to conduct surgery and sensors from which to capture ...
Pietro Mascagni   +12 more
doaj   +1 more source

Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae

open access: yesBiology, 2021
Artificial sweeteners are widely used food ingredients in beverages and drinks to lower calorie intake which in turn helps prevent lifestyle diseases such as obesity.
Ferry Saputra   +6 more
doaj   +1 more source

Artificial intelligence for the diagnosis of heart failure

open access: yesnpj Digital Medicine, 2020
The diagnosis of heart failure can be difficult, even for heart failure specialists. Artificial Intelligence-Clinical Decision Support System (AI-CDSS) has the potential to assist physicians in heart failure diagnosis.
D. Choi   +3 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Estimating infant age from skull X-ray images using deep learning

open access: yesScientific Reports
This study constructed deep learning models using plain skull radiograph images to predict the accurate postnatal age of infants under 12 months. Utilizing the results of the trained deep learning models, it aimed to evaluate the feasibility of employing
Heui Seung Lee   +4 more
doaj   +1 more source

Ferroptosis and Autophagy-Related Genes in the Pathogenesis of Ischemic Cardiomyopathy

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundObesity plays an important role in type 2 diabetes mellitus (T2DM) and myocardial infarction (MI). Ferroptosis and ferritinophagy are related to metabolic pathways, such as fatty acid metabolism and mitochondrial respiration.
Yue Zheng   +32 more
doaj   +1 more source

Artificial Heart Valves [PDF]

open access: yesJAMA, 2021
William C, Frankel, Tom C, Nguyen
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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