Results 171 to 180 of about 192,679 (274)

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Smart Optogenetics for Real‐Time Automated Control of Cardiac Electrical Activity

Advanced Science, EarlyView.
We are able to stop dangerous heart‐rhythm spirals before they fully form. Within about 100 ms, it pinpoints the spiral's tiny central tip (≈0.9 mm) using light‐based sensing and machine learning, then shines targeted light to shut it down. This fast, precise, closed‐loop approach detects, targets, and terminates arrhythmias in real time.
Shanliang Deng, Niels Harlaar, Juan Zhang, Sven O. Dekker, Nina N. Kudryashova, Huiling Zhou, Cindy I. Bart, TianYi Jin, Georgy Derevyanko, Willem van Driel, Alexander V. Panfilov, René H. Poelma, Antoine A. F. de Vries, GuoQi Zhang, Tim De Coster, Daniël A. Pijnappels   +15 more
wiley   +1 more source

Prediction of Received Heart and Lung Radiation Dose in Breast Cancer Patients Undergoing Radiation Therapy Using Supervised Machine Learning [PDF]

Pooria Afsharifard, Mohammad Bagher Dowlatshahi, Mohammad Abbasi, Abbas Rezaeian, M Amraei   +4 more
openalex   +1 more source

Heart-Lung Machine: Seven Decades of Challenging Work [PDF]

, 2018
Yasser Ali Kamal
openalex   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injury. [PDF]

PeerJ
Zhu L, Ding J, Wei D, Chen J.
europepmc   +1 more source

Usefulness of Modified Ultrafiltration after removal of heart-lung machine desorption of infant.

, 1998
TOORU MATAYOSHI
openalex   +2 more sources

Hypothermia and the Heart-Lung Machine [PDF]

, 1960
Donald N. Ross
openalex   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

The Top 12 Most Impactful Papers in Clinical Transplantation in 2025: TI Editors' Choice. [PDF]

Transpl Int
Berney T, Becchetti C, Bellini MI, Benning L, Berishvili E, Bestard O, Bos S, Brouard S, Casiraghi F, Citro A, Couzi L, Jimenez-Blanco M, Kervella D, Lim WH, Manuel O, Pilat N, Schneeberger S, Seizilles de Mazancourt E, Selzner N, Thaunat O, Toso C, Trizzino A, Yahav D, Zajacova A.   +23 more
europepmc   +1 more source