Results 51 to 60 of about 57,851 (263)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

CHD-CXR: a de-identified publicly available dataset of chest x-ray for congenital heart disease

Frontiers in Cardiovascular Medicine
Congenital heart disease is a prevalent birth defect, accounting for approximately one-third of major birth defects. The challenge lies in early detection, especially in underdeveloped medical regions where a shortage of specialized physicians often ...
Li Zhixin, Luo Gang, Ji Zhixian, Wang Sibao, Pan Silin   +4 more
doaj   +1 more source

Testing and Simulation of Multilayer Polyvinylidene Fluoride‐Based Piezoelectric Energy Harvester Devices

Advanced Materials Technologies, EarlyView.
The study considers the use of polymer/dielectric‐based multilayers piezoelectric Energy Harvesters (EH) to produce an output voltage and current, by exploiting the mechanical energy provided by human organs movements. In particular, the heart motion is considered from the kinematic viewpoint, and a multiphysics theoretical model is developed to assess
Hamdi Ezzin, Silvia Monchetti, Paolo Emilio Puddu, Luciano Teresi, Antonio DeSimone, Roberto Brighenti   +5 more
wiley   +1 more source

SenSet defines cell-type specific senescence signatures in the aged human lung

The EMBO Journal
Cellular senescence is defined as an irreversible growth arrest observed when cells are exposed to a variety of stressors, including DNA damage, oxidative stress, or nutrient deprivation.
Euxhen Hasanaj, Delphine Beaulieu, Cankun Wang, Qianjiang Hu, Lorena Rosas, Marta Bueno, John C Sembrat, Ricardo H Pineda, Maria Camila Melo-Narvaez, Nayra Cardenes, Zhao Yanwu, Zhang Yingze, Robert Lafyatis, Alison Morris, Ana Mora, Mauricio Rojas, Dongmei Li, Irfan Rahman, Gloria S Pryhuber, Mareike Lehmann, Jonathan Alder, Aditi Gurkar, Toren Finkel, Qin Ma, Jose Lugo-Martinez, Barnabás Póczos, Ziv Bar-Joseph, Oliver Eickelberg, Melanie Königshoff   +28 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Network pharmacological modeling of anti-lung cancer prescription Baihe Gujin Pill based on meridian differentiation with machine learning

Results in Chemistry
It is believed that the occurrence of lung cancer is resulting from the block and injury of lung meridian in traditional Chinese medicine (TCM). The clinical decoctions with lung meridian tropism can nourish yin and moisten the lung as well as clear heat
Sheng Zhang, Hongying Liu, Bochu Wang
doaj   +1 more source

Successful management of penetrating cardiac injury in a limited resource setting without cardiac surgical instruments and heart-lung machine. [PDF]

J Surg Case Rep, 2023
Ammannaya GKK.
europepmc   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Machine Learning for 1-Year Mortality Prediction in Lung Transplant Recipients: ISHLT Registry

Transplant International
Optimizing lung transplant candidate selection is crucial for maximizing resource efficiency and improving patient outcomes. Using data from the International Society for Heart and Lung Transplantation (ISHLT) registry (29,364 patients), we developed a ...
Hye Ju Yeo, Hye Ju Yeo, Dasom Noh, Eunjeong Son, Eunjeong Son, Sunyoung Kwon, Sunyoung Kwon, Sunyoung Kwon, Woo Hyun Cho, Woo Hyun Cho   +9 more
doaj   +1 more source