Results 31 to 40 of about 56,070 (265)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Generative AI Respiratory and Cardiac Sound Separation Using Variational Autoencoders (VAEs)

Computer Sciences & Mathematics Forum
The separation of respiratory and cardiac sounds is a significant challenge in biomedical signal processing due to their overlapping frequency and time characteristics.
Arshad Jamal, R. Kanesaraj Ramasamy, Junaidi Abdullah   +2 more
doaj   +1 more source

Classification of COVID-19 associated symptomatology using machine learning

Dyna, 2023
The health situation caused by the SARS-Cov2 coronavirus, posed major challenges for the scientific community. Advances in artificial intelligence are a very useful resource, but it is important to determine which symptoms presented by positive cases of
Julian Andres Ramirez-Bautista, Silvia L. Chaparro-Cárdenas , Wilson Gamboa-Contreras, William Guerrero-Salazar , Jorge Adalberto Huerta-Ruelas   +4 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

The history of cardiopulmonary bypass and the evolution of pneuma in cardiopulmonary medicine

Archives of Medical Science: Atherosclerotic Diseases
Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs.
Vasileios Leivaditis, Georgios Mavroudes, Hermann Braun Lambur, Nikolaos Baikoussis, Elias Liolis, Konstantinos Tasios, Levan Tchabashvili, George Theofanis, Andreas Antzoulas, Dimitrios Litsas, Panagiotis Dimitrios Papadopoulos, Konstantinos Nikolakopoulos, Manfred Dahm, Spyros Papadoulas, Francesk Mulita   +14 more
doaj   +1 more source

Accuracy of trans-thoracic echocardiography as a pericardial diseases diagnostic tool

Ibom Medical Journal, 2006
Summary A prospective comparison of pre-operative trans-thoracic echocardiographic findings with intra-operative findings of 17 patients operated on for pericardial diseases showed excellent correlation for pericardial calcification and adhesion, and ...
Ekpe EE, Anyanwu CH
doaj   +1 more source

The Role of Perfusionists during the COVID-19 Pandemic and Clinical Laboratory Technologists: Comparison of Training Systems in Japan and the United States

Korean Journal of Clinical Laboratory Science, 2022
In 2022, Korea reported a total of 224 perfusionists, employing nurses or clinical laboratory technologists (also known as medical technologists) to provide hospital self-education or reliable education.
Dong-Ok Aum, Dae Jin Kim, Dae Eun Kim, Myong Soo Kim, Bon-Kyeong Koo   +4 more
doaj   +1 more source