Results 31 to 40 of about 237,766 (311)

Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia [PDF]

, 2006
Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in
Brown, C. McCabe, Chou, Doutheil, E. Morton, F. White, Fornace, Hannan, Harland, He, Hollander, Horman, I.M. Macrae, Imai, S.M. Brown, White   +15 more
core   +1 more source

Beyond dichotomy: patterns and amplitudes of SSEPs and neurological outcomes after cardiac arrest

Critical Care, 2019
Background We hypothesized that the absence of P25 and the N20–P25 amplitude in somatosensory evoked potentials (SSEPs) have higher sensitivity than the absence of N20 for poor neurological outcomes, and we evaluated the ability of SSEPs to predict long ...
Sang Hoon Oh, Kyu Nam Park, Seung Pill Choi, Joo Suk Oh, Han Joon Kim, Chun Song Youn, Soo Hyun Kim, Kiyuk Chang, Seong Hoon Kim   +8 more
doaj   +1 more source

Comparison of outcomes between cardiogenic and non-cardiogenic cardiac arrest patients receiving targeted temperature management: The nationwide TIMECARD multicenter registry

Journal of the Formosan Medical Association, 2023
Background and purpose: Targeted temperature management (TTM) has been recommended for post-resuscitation care of cardiac arrest (CA) patients who remain comatose.
Mei-Tzu Wang, Min-Shan Tsai, Chien-Hua Huang, Li-Kuo Kuo, Hsinhui Hsu, Chih-Hung Lai, Kun Chang Lin, Wei-Chun Huang   +7 more
doaj   +1 more source

Therapeutic Hypothermia after Prolonged Cardiac Arrest: Case Report with Review of Literature [PDF]

Journal of Clinical and Diagnostic Research, 2015
Patients who survive cardiac arrest often develop severe neurological dysfunction due to the hypoxic brain injury and reperfusion induced cell death.
Gautam Rawal, Sankalp Yadav, Nitin Garg
doaj   +1 more source

Non-Invasive Monitoring of Core Body Temperature for Targeted Temperature Management in Post-Cardiac Arrest Care

Frontiers in Medicine, 2022
ImportanceAccurate monitoring of core body temperature is integral to targeted temperature management (TTM) following cardiac arrest. However, there are no reliable non-invasive methods for monitoring temperature during TTM.ObjectivesWe compared the ...
Kyle Fiorini, Kyle Fiorini, Tanya Tamasi, Justin Dorie, Ahmed F. Hegazy, Ahmed F. Hegazy, Ting-Yim Lee, Ting-Yim Lee, Marat Slessarev, Marat Slessarev, Marat Slessarev   +10 more
doaj   +1 more source

Therapeutic hypothermia and neurological outcome after cardiac arrest [PDF]

Vojnosanitetski Pregled, 2011
Introduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation.
Petrović Milovan, Panić Gordana, Jovelić Aleksandra, Čanji Tibor, Srdanović Ilija, Popov Tanja, Golubović Miodrag   +6 more
doaj   +1 more source

Modulation of Mitochondrial Bioenergetics in the Isolated Guinea Pig Beating Heart by Potassium and Lidocaine Cardioplegia: Implications for Cardioprotection [PDF]

, 2009
Mitochondria are damaged by cardiac ischemia/reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against ...
Aldakkak, Mohammed, Camara, Amadou K.S., Chen, Qun, Heisner, James S., Lesnefsky, Edward J., Stowe, David F.   +5 more
core   +2 more sources

Omecamtiv mecarbil treatment improves post-resuscitation cardiac function and neurological outcome in a rat model.

PLoS ONE, 2022
BackgroundMyocardial dysfunction is a major cause of poor outcomes in the post-cardiac arrest period. Omecamtiv mecarbil (OM) is a selective small molecule activator of cardiac myosin that prolongs myocardial systole and increases stroke volume without ...
Shih-Ni Wu, Min-Shan Tsai, Chien-Hua Huang, Wen-Jone Chen   +3 more
doaj   +2 more sources

Comparative experimental study of myocardial protection with crystalloid solutions for heart transplantation Estudo comparativo experimental da proteção miocárdica com soluções cristalóides para transplante cardíaco

Brazilian Journal of Cardiovascular Surgery, 2012
BACKGROUND: There is a growing need to improve myocardial protection, which will lead to better performance of cardiac operations and reduce morbidity and mortality.
Melchior Luiz Lima, Alfredo Inácio Fiorelli, Dalton Valentim Vassallo, Bruno Botelho Pinheiro, Noedir Antonio Groppo Stolf, Otoni Moreira Gomes   +5 more
doaj   +1 more source

Targeted Temperature Management at 36°C after In-Hospital Cardiac Arrest Trial (TTM-36 IHCA Trial): Study Protocol for an Investigator-Initiated, Single-Center, Randomized, Controlled, Assessor-Blinded, Pilot Clinical Trial [PDF]

Journal of Neurocritical Care, 2016
Background: Targeted temperature management (TTM) has neuroprotective effects in comatose patients despite restoration of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest.

doaj   +1 more source