Results 91 to 100 of about 2,119,388 (341)

Fast characterization of inducible regions of atrial fibrillation models with multi-fidelity Gaussian process classification [PDF]

arXiv, 2021
Computational models of atrial fibrillation have successfully been used to predict optimal ablation sites. A critical step to assess the effect of an ablation pattern is to pace the model from different, potentially random, locations to determine whether arrhythmias can be induced in the atria.
arxiv  

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia   +19 more
wiley   +1 more source

How random is your heart beat? [PDF]

, 2006
We measure the content of random uncorrelated noise in heart rate variability using a general method of noise level estimation using a coarse grained entropy.
Baselli, Bayés da Luna, Cencini, Costa, Denton, Eke, Grassberger, Groome, He, Jan J. Żebrowski, Janusz A. Hołyst, Krzysztof Urbanowicz, Kuusela, Kuusela, Marwan, Naschitz, Rafał Baranowski, Stanley, Stanley, Stein, Stein, Thiel, Urbanowicz, Urbanowicz, Voss, Wei, Wu, Yulmetyev, Żebrowski, Żebrowski, Żebrowski   +30 more
core   +2 more sources

The absence of dystrophin brain isoform expression in healthy human heart ventricles explains the pathogenesis of 5' X-linked dilated cardiomyopathy

BMC Medical Genetics, 2012
Background In X-linked dilated cardiomyopathy due to dystrophin mutations which abolish the expression of the M isoform (5'-XLDC), the skeletal muscle is spared through the up-regulation of the Brain (B) isoform, a compensatory mechanism that does not ...
Neri Marcella, Valli Emanuele, Alfano Giovanna, Bovolenta Matteo, Spitali Pietro, Rapezzi Claudio, Muntoni Francesco, Banfi Sandro, Perini Giovanni, Gualandi Francesca, Ferlini Alessandra   +10 more
doaj   +1 more source

Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. [PDF]

PLoS ONE, 2015
The functional importance of threonine 5 (T5) in modulating the activity of sarcolipin (SLN), a key regulator of sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA) pump was studied using a transgenic mouse model with cardiac specific expression of ...
Mayilvahanan Shanmugam, Dan Li, Shumin Gao, Nadezhda Fefelova, Vikas Shah, Antanina Voit, Ronald Pachon, Ghassan Yehia, Lai-Hua Xie, Gopal J Babu   +9 more
doaj   +1 more source

Modeling specific action potentials in the human atria based on a minimal reaction-diffusion model [PDF]

, 2017
We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale.
arxiv   +1 more source

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

Advanced Science, EarlyView.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou, Bing Dong, Dayu He, Jianshuai Ma, Yun Kong, Huijin Zhu, Chen Xie, Tiecheng Yang, Xin Zhen, Zhengzhipeng Zhang, Zhaohui He, Jinkun Cheng, Aoran Huang, Jie Chen, Ruo Wu, Huiyong Yin, Yanlian Chen, Jun Tao, Hui Huang   +18 more
wiley   +1 more source

Reflex responses from the main pulmonary artery and bifurcation in anaesthetised dogs [PDF]

, 2000
This study was undertaken to determine the reflex cardiovascular and respiratory responses to discrete stimulation of pulmonary arterial baroreceptors using a preparation in which secondary modulation of responses from other reflexes was prevented.
Drinkhill, M.J., Hainsworth, R., McMahon, N.C., Myers, D.S.   +3 more
core   +1 more source

CLINICAL CASE OF MULTIPLE HEART TUMORS IN NEWBORN

Мать и дитя в Кузбассе, 2019
Heart tumors are a rare pathology, especially in children. They have a varied characteristic. This disease can affect any part of the organ, the pericardium, the myocardium, the valves, the internal tissue of the heart, as well as the septum between the ...
Елена Викторовна Гольцман, Ольга Викторовна Полонская, Ольга Владиславовна Кучма, Дмитрий Александрович Маисеенко, Марина Юрьевна Галактионова   +4 more
doaj  

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source