Results 71 to 80 of about 1,438,452 (291)
BMC Medical Genetics, 2012 Background In X-linked dilated cardiomyopathy due to dystrophin mutations which abolish the expression of the M isoform (5'-XLDC), the skeletal muscle is spared through the up-regulation of the Brain (B) isoform, a compensatory mechanism that does not ...
Neri Marcella +10 more
doaj +1 more source
Advanced Science, EarlyView.Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao +5 more
wiley +1 more source
Vasoactive Intestinal Polypeptide in Rat Heart Atria: the Effect of Hyperthyroidism
Physiological Research, 2000 The effects of transient and sustained hyperthyroidism on vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) levels were studied in the heart atria of developing and adult rats. Newborn rats were divided into 5 groups. Neo-T animals were treated with thyroxine (T4) during postnatal days 1-8 and sacrificed at the age of 60 days. Neo-S rats
J, Kuncová, J, Slavíková
openaire +2 more sources
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome.
PLoS ONESinoatrial node (SAN) dysfunction often accompanies supraventricular tachyarrhythmias such as atrial fibrillation (AF), which is referred to as tachycardia-bradycardia syndrome (TBS). Although there have been many studies on electrical remodeling in TBS,
Shunsuke Baba +6 more
doaj +1 more source
Recurrent left-sided heart leiomyosarcoma: should heart transplantation be legitimate?
, 1998 Leiomyosarcoma of the heart is an uncommon primary malignant tumor with poor postoperative survival that may be measured in months. A leiomyosarcoma of the left atrium was diagnosed in a 47-year-old man.
Massetti, Massimo
core
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi +7 more
wiley +1 more source
Advanced Science, EarlyView.MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant +14 more
wiley +1 more source
Influence of Torso Model Complexity on the Noninvasive Localization of Ectopic Ventricular Activity
Measurement Science Review, 2016 Location of premature ectopic ventricular activity was assessed noninvasively in five patients using integral body surface potential maps and inverse solution in terms of a single dipole.
Punshchykova Olena +8 more
doaj +1 more source
Supraventricular Tachycardia in Children
Педиатрическая фармакология, 2019 Rhythm and conduction disorders of the heart occupy one of the leading places in the structure of cardiovascular pathology in children. Supraventricular tachycardias means tachyarrhythmias, caused by abnormal myocardial excitation with the source of ...
Igor A. Kovalev +7 more
doaj +1 more source