Results 81 to 90 of about 2,184,778 (369)

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. [PDF]

PLoS ONE, 2015
The functional importance of threonine 5 (T5) in modulating the activity of sarcolipin (SLN), a key regulator of sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA) pump was studied using a transgenic mouse model with cardiac specific expression of ...
Mayilvahanan Shanmugam, Dan Li, Shumin Gao, Nadezhda Fefelova, Vikas Shah, Antanina Voit, Ronald Pachon, Ghassan Yehia, Lai-Hua Xie, Gopal J Babu   +9 more
doaj   +1 more source

Flexible Sensor‐Based Human–Machine Interfaces with AI Integration for Medical Robotics

Advanced Robotics Research, EarlyView.
This review explores how flexible sensing technology and artificial intelligence (AI) significantly enhance human–machine interfaces in medical robotics. It highlights key sensing mechanisms, AI‐driven advancements, and applications in prosthetics, exoskeletons, and surgical robotics.
Yuxiao Wang, Zhipeng Jiang, Sun Hwa Kwon, Matthew Ibrahim, Alexander Dang, Lin Dong   +5 more
wiley   +1 more source

Structural and functional characteristics of myocard in patients with different forms of atrial fibrillation

Zaporožskij Medicinskij Žurnal, 2015
Aim. To study structural and functional characteristics of myocard in patients with different forms of atrial fibrillation. Atrial fibrillation is the most prevalent arrhythmia in clinical practice.
L. I. Vasilyeva , S. O. Pyvovarova, L. V. Sapozhnychenko, O. S. Kalashnykova, V. G. Dzyak   +4 more
doaj   +1 more source

Incidence and predictors of premature ventricular complexes following catheter ablation for atrial fibrillation [PDF]

, 2017
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and previous studies have focused on the epidemiology, mechanisms and risk factors for this global disease (Ryder and Benjamin 1999). Various studies have examined the mechanism,
Harvey, Joshua
core  

Recent Advances in Variable‐Stiffness Robotic Systems Enabled by Phase‐Change Materials

Advanced Robotics Research, EarlyView.
Phase‐change materials (PCMs), such as shape memory alloys, hydrogels, shape memory polymers, liquid crystal elastomers, and low‐melting‐point alloys, are driving advancements in stiffness‐tunable robotic systems across a wide range of applications. This review highlights recent progress in PCM‐enabled robotics, focusing on their underlying mechanisms,
Sukrit Gaira, Liao Wu, Ming Li, Priyank Kumar, Xiaopeng Li, Shi‐Yang Tang   +5 more
wiley   +1 more source

Transcriptional analysis of the mammalian heart with special reference to its endocrine function

BMC Genomics, 2009
Background Pharmacological and gene ablation studies have demonstrated the crucial role of the endocrine function of the heart as mediated by the polypeptide hormones ANF and BNP in the maintenance of cardiovascular homeostasis.
de Bold Adolfo J, McGrath Monica
doaj   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

CLINICAL CASE OF MULTIPLE HEART TUMORS IN NEWBORN

Мать и дитя в Кузбассе, 2019
Heart tumors are a rare pathology, especially in children. They have a varied characteristic. This disease can affect any part of the organ, the pericardium, the myocardium, the valves, the internal tissue of the heart, as well as the septum between the ...
Елена Викторовна Гольцман, Ольга Викторовна Полонская, Ольга Владиславовна Кучма, Дмитрий Александрович Маисеенко, Марина Юрьевна Галактионова   +4 more
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