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The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Postoperative arrhythmia in patients with bidirectional cavopulmonary anastomosis [PDF]
OBJECTIVES Bidirectional cavopulmonary anastomosis (BDCPA) is part of the staged Fontan palliation for congenital heart defects with single-ventricle morphology.
Balmer, Christian +5 more
core
Seckel syndrome presenting with complete heart block
Mostafa Abohelwa +4 more
openalex +2 more sources
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
Automatic diagnosis of heart diseases branch block [PDF]
Los electrocardiogramas (ECG) registran la actividad eléctrica del corazón a través de doce señales principales denominadas derivaciones. Estas derivaciones son analizadas por expertos médicos observando aquellos segmentos de la señal eléctrica que ...
Tenorio Serrano, Emilio
core
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Aim: Junctional ectopic tachycardia (JET) is a postoperative complication with a mortality rate of up to 14% after surgery for congenital heart disease. This study evaluated the risk factors of JET and explored the association of postoperative temporary ...
Christian Paech +4 more
doaj +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Postoperative arrhythmia in pediatric intensive care unit
Postoperative arrhythmias are a significant concern in pediatric patients following cardiac surgery, with an incidence ranging from 7.5% to 48%. These arrhythmias, classified into tachyarrhythmias and bradyarrhythmias, can be triggered by multiple ...
Riyan Sukumar Shetty +3 more
doaj +1 more source

