Results 101 to 110 of about 1,294,434 (350)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Association of temporary complete AV block and junctional ectopic tachycardia after surgery for congenital heart disease

Annals of Pediatric Cardiology, 2015
Aim: Junctional ectopic tachycardia (JET) is a postoperative complication with a mortality rate of up to 14% after surgery for congenital heart disease. This study evaluated the risk factors of JET and explored the association of postoperative temporary ...
Christian Paech, Ingo Dähnert, Martin Kostelka, Meinhardt Mende, Roman Gebauer   +4 more
doaj   +1 more source

Response to Ryan and Parwani: Heart Failure Patients With Low Blood Pressure: How Should We Manage Neurohormonal Blocking Drugs? [PDF]

, 2012
Biykem Bozkurt
openalex   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cardiac Arrhythmias and Conduction Disorders as the Main Manifestation of Chagas Myocarditis

Juvenis Scientia
Introduction. Chagas disease is an infectious vector — borne disease caused by the protozoa Trypanosoma cruzi. The main manifestation of the chronic course of Chagas disease is myocarditis, which leads to chamber dilation, congestive heart failure, and ...
Timofeev, E.V., Nguba Muana, M.A., Antipov, M.N.   +2 more
doaj   +1 more source

Automatic diagnosis of heart diseases branch block [PDF]

, 2016
Los electrocardiogramas (ECG) registran la actividad eléctrica del corazón a través de doce señales principales denominadas derivaciones. Estas derivaciones son analizadas por expertos médicos observando aquellos segmentos de la señal eléctrica que ...
Tenorio Serrano, Emilio
core  

Rheumatic Carditis with Complete Heart Block [PDF]

, 1929
Wilfrid Sheldon
openalex   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Remodelamento ventricular na estimulação cardíaca apical do ventrículo direito Ventricular remodeling in right ventricular apical pacing

Arquivos Brasileiros de Cardiologia, 2007
OBJETIVO: Avaliar a taxa de remodelamento ventricular (RV) e a importância de variáveis clínico-funcionais em pacientes com função cardíaca normal submetidos à estimulação artificial apical do ventrículo direito (VD).
Rodrigo Tavares Silva, Martino Martinelli Filho, Júlio César de Oliveira, Carlos Eduardo Batista de Lima, Daniela Garcia Moreno Cabral Martins, Cinthya Ibraim Guirao, Silvana Angelina Dório Nishióka, Roberto Costa, Eduardo Argentino Sosa, José Antonio Franchini Ramires   +9 more
doaj   +1 more source