Results 51 to 60 of about 1,265,417 (348)
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Blocking transport resonances via Kondo entanglement in quantum dots [PDF]
, 2016 Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and
Cleuziou, J. -P. +7 more
core +3 more sources
Differential Effects of Vagal Activation on the Sinus and Atrioventricular Nodes
JACC: Case Reports, 2020 Vagal activation usually affects both sinus and atrioventricular (AV) nodes, manifesting as sinus slowing accompanied by varying degrees of AV block. AV block accompanying sinus acceleration as during treadmill testing is usually considered pathologic ...
Lauren D. Suggs, MD +2 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Predicting the development of cardiac arrhythmias and cardiac conduction disorders in patients [PDF]
КардиоСоматика, 2017 The article is devoted to descriftion of the new method for diagnostics and predicting of the development of risk for development of cardiac arrhythmias and cardiac conduction disorders in patients by using of the computer system. For oftimization of the
S. Yu Nicoulina +3 more
doaj
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Heart block and paragonimiasis. [PDF]
Heart, 1988 Intracardiac granulomas can cause complete heart block. A case of complete heart block is reported in a patient who had had paragonimiasis 30 years before and who had radiographic evidence of calcified granulomas in the heart and lungs.
M C Petch, W L Morrison
openaire +3 more sources
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions [PDF]
, 2015 This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria.
Bayés de Luna +61 more
core +5 more sources