Results 191 to 200 of about 187,698 (309)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Adolescent with Unexplained Cardiac Hypertrophy, Ventricular Pre-Excitation, Conduction System Disease: PRKAG2 Cardiac Syndrome as a Rare Mimicker of Hypertrophic Cardiomyopathy. [PDF]

Anatol J Cardiol
Guo Y, Yi D, Liu D, Fan Q, Ma Z, Wang L, Chen H, Wang B, Yan H.   +8 more
europepmc   +1 more source

From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements

Advanced Functional Materials, EarlyView.
Bioprosthetic aortic valves have revolutionized the treatment of aortic stenosis, but their durability is limited by structural valve deterioration (SVD). This review focuses on the pericardial tissue at the heart of these valves, examining how its mechanical properties and calcification drive fatigue and failure.
Gabriele Greco, Pierfrancesco Gaziano, Serena Anglese, Simone Morganti, Carlo de Vincentiis, Ferdinando Auricchio, Michele Marino, Michele Conti   +7 more
wiley   +1 more source

Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression. [PDF]

JCI Insight
Joo K, Matsuoka R, Kitajima K, Yashiro K, Shiose A, Tominaga R, Shen MM, Oki S, Meno C.   +8 more
europepmc   +1 more source

Breathable Graphene Oxide‐Polymer Composite Membranes With Two‐Step Barrier Mechanism Against Nerve Agents

Advanced Functional Materials, EarlyView.
ABSTRACT Breathable membranes that reject chemical warfare agents (CWAs) are required for next‐generation protective apparel. A dual‐function graphene oxide (GO)‐polyamine architecture is introduced that addresses the long‐standing tradeoff between vapor transmission and CWA selectivity.
Hyungjun Kim, Chanui Lee, Keunhong Jeong, Seonggi Kim, Hyunju Shin, Sunghan Kim, Youngho Jin   +6 more
wiley   +1 more source

Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial.

JAMA Cardiol
Zimerman A, Dal Forno A, Rohde LE, Ternes CM, Alves FD, Damiani LP, Martinelli-Filho M, Costa R, Fagundes AA, Barbosa RM, Gadelha EB, Lima CE, Silva MA, Maldonado JA, de Oliveira JC, Mallmann F, Baggio Júnior JM, Duarte CE, de Souza LA, Santos JS, Silveira AD, Decker SRR, Zimerman LI, Polanczyk CA, d'Avila A.   +24 more
europepmc   +1 more source

Conduction system pacing using a rotatable connector enabling continuous pacing during lumenless lead deployment: a case report. [PDF]

Eur Heart J Case Rep
Montenegro Sá F, Castro A, Pereira S, Gavina C.   +3 more
europepmc   +1 more source

Anomalous Pressure‐Temperature Ultrahigh Sensitivities in Atomically Engineered Carbonitride MXenes for Multifunctional Wearable Human–Machine Interfaces: Joint Computational–Experimental Elucidations

Advanced Functional Materials, EarlyView.
Atomically engineered layered 2D Ti3CNTz carbonitride MXene exhibits ultrahigh heat and pressure sensitivity, enabling dual‐mode sensors with 300%–400% performance enhancement and durability for real‐time health‐monitoring interface devices. Precise nitrogen incorporation (e.g., Ti3C1.8N0.2Tz) boosts conductivity, enhancing temperature response, while ...
Debananda Mohapatra, Ju‐Hyoung Han, Hyun Jin Kang, Jeong Eun Byun, Seonghun Lee, Sanghyuk Lee, Yeseul Son, Jaeeun Park, Tae Joo Shin, Youngho Kang, Jung Woo Lee, Soon‐Yong Kwon, Soo‐Hyun Kim   +12 more
wiley   +1 more source

Immune checkpoint inhibitor-induced myocarditis with atrioventricular conduction abnormalities: a case report. [PDF]

ESMO Gastrointest Oncol
Strijdhorst A, Opstal TSJ, Robbers LFHJ, Labots M, van Laarhoven HWM.   +4 more
europepmc   +1 more source