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Development and Function of the Cardiac Conduction System in Health and Disease [PDF]

Journal of Cardiovascular Development and Disease, 2017
The generation and propagation of the cardiac impulse is the central function of the cardiac conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of automaticity, but slow conduction properties.
David S. Park, Glenn I. Fishman
doaj   +5 more sources

Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease

Journal of Arrhythmia
Background Conduction system disease may represent an early manifestation of underlying structural heart disease, including infiltrative disorders.
Jeremy William, Haider Muthana, Joseph Hogarty, Andrew Taylor, James L. Hare, Justin Mariani, Hitesh Patel, Geoff Wong, Dion Stub, David M. Kaye, Sandeep Prabhu, Peter M. Kistler, Aleksandr Voskoboinik   +12 more
doaj   +4 more sources

Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease

Frontiers in Cell and Developmental Biology, 2021
Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death.
Rui Gao, Jie Ren
doaj   +3 more sources

Current Topics of Progressive Cardiac Conduction Disease [PDF]

Journal of Arrhythmia
Progressive cardiac conduction disease (PCCD) is a rare inheritable cardiac conduction system disease that may lead to complete heart block, syncope, or sudden cardiac death. The estimated incidence of PCCD is 0.0005%/year.
Naokata Sumitomo, Hitoshi Mori, Takashi Kumamoto, Taisuke Ishikawa, Akiko Seki, Naomasa Makita, Jean‐Jacques Schott, Arthur A. M. Wilde   +7 more
doaj   +2 more sources

Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease

PLoS ONE, 2021
Background Lyme carditis, defined as direct infection of cardiac tissue by Borrelia bacteria, affects up to 10% of patients with Lyme disease. The most frequently reported clinical manifestation of Lyme carditis is cardiac conduction system disease.
Uwajachukwumma A. Uzomah, Guy Rozen, Seyed Mohammadreza Hosseini, Ayman Shaqdan, Pablo A. Ledesma, Xuejing Yu, Pegah Khaloo, Jennifer Galvin, Leon M. Ptaszek, Jeremy N. Ruskin   +9 more
doaj   +2 more sources

Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes

Journal of Cardiovascular Development and Disease, 2021
The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart.
Drew Nassal, Jane Yu, Dennison Min, Cemantha Lane, Rebecca Shaheen, Daniel Gratz, Thomas J. Hund   +6 more
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Left Bundle Branch Pacing in Transthyretin Cardiac Amyloidosis and Alternating Bundle Branch Block

JACC: Case Reports, 2020
Progressive conduction system disease affects patients with transthyretin cardiac amyloidosis, often requiring permanent pacing as the His-Purkinje system is affected. We present a case of left bundle branch pacing in a patient with transthyretin cardiac
Taha Ahmed, MD, Samra Haroon Lodhi, MBBS, Hassan Lak, MD, Jae Lee, MD, Mazen Hanna, MD, Roy Chung, MD   +5 more
doaj   +1 more source

Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells

iScience, 2022
Summary: Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction ...
Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H. Gunaratne, Na Li, Robert J. Schwartz, Bradley K. McConnell   +11 more
doaj   +1 more source

Engineering a conduction-consistent cardiac patch with rGO/PLCL electrospun nanofibrous membranes and human iPSC-derived cardiomyocytes

Frontiers in Bioengineering and Biotechnology, 2023
The healthy human heart has special directional arrangement of cardiomyocytes and a unique electrical conduction system, which is critical for the maintenance of effective contractions.
Yao Tan, Ying Chen, Tingting Lu, Nevin Witman, Bingqian Yan, Yiqi Gong, Xuefeng Ai, Li Yang, Li Yang, Minglu Liu, Runjiao Luo, Huijing Wang, Stefano Ministrini, Stefano Ministrini, Wei Dong, Wei Wang, Wei Fu, Wei Fu   +17 more
doaj   +1 more source

Desmin variants: Trigger for cardiac arrhythmias?

Frontiers in Cell and Developmental Biology, 2022
Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su, Wei Su, Stan W. van Wijk, Stan W. van Wijk, Bianca J. J. M. Brundel, Bianca J. J. M. Brundel   +5 more
doaj   +1 more source